Multidrug resistance profile in Lactobacillus delbrueckii: a food industry species with probiotic properties

• Published in: World journal of microbiology & biotechnology 2024-08, Vol.40 (8), p.235, Article 235
• Main Authors: Quaresma, Ludmila Silva, Santos, Rhayane Cristina Viegas, Gomes, Gabriel Camargos, Américo, Monique Ferrary, Campos, Gabriela Munis, Laguna, Juliana Guimarães, Barroso, Fernanda Alvarenga Lima, Azevedo, Vasco, de Jesus, Luís Cláudio Lima
• Format: Article
• Language: English
• Subjects: Aminoglycosides; Anti-Bacterial Agents - pharmacology; Antibiotic resistance; Antibiotics; Applied Microbiology; Biochemistry; Biomedical and Life Sciences; Biotechnology; Ciprofloxacin; Drug resistance; Drug Resistance, Multiple, Bacterial - genetics; Environmental Engineering/Biotechnology; Fermented food; Fermented Foods - microbiology; Fermented milk products; Fluoroquinolones; Food Industry; Food Microbiology; Genes; Genetic factors; Gentamicin; Glycopeptides; Industrial safety; Kanamycin; Lactic acid; Lactobacilli; Lactobacillus delbrueckii; Lactobacillus delbrueckii - drug effects; Lactobacillus delbrueckii - genetics; Life Sciences; Microbiology; Multidrug resistance; Probiotics; Probiotics - pharmacology; Review; Risk reduction; Streptomycin; Tetracyclines; Vancomycin
• ISSN: 0959-3993; 1573-0972; 1573-0972
• DOI: 10.1007/s11274-024-04046-3

Lactobacillus delbrueckii , a widely used lactic acid bacterium in the food industry, has been studied for its probiotic properties and reservoir of antibiotic-resistant genes, raising safety concerns for probiotic formulations and fermented products. This review consolidates findings from 60 articles published between 2012 and 2023, focusing on the global antibiotic resistance profile and associated genetic factors in L. delbrueckii strains. Resistance to aminoglycosides, particularly streptomycin, kanamycin, and gentamicin, as well as resistance to glycopeptides (vancomycin), fluoroquinolones (ciprofloxacin), and tetracyclines was predominant. Notably, although resistance genes have been identified, they have not been linked to mobile genetic elements, reducing the risk of dissemination. However, a significant limitation is the insufficient exploration of responsible genes or mobile elements in 80% of studies, hindering safety assessments. Additionally, most articles originated from Asian and Middle Eastern countries, with strains often isolated from fermented dairy foods. Therefore, these findings underscore the necessity for comprehensive analyses of new strains of L. delbrueckii for potential industrial and biotherapeutic applications and in combating the rise of antibiotic-resistant pathogens.