Impact of red blood cell transfusion and hemoglobin threshold on 1-year mortality among surgical sepsis survivors: A propensity score matching study

Despite the fact that red blood cell (RBC) transfusion is commonly applied in surgical intensive care unit (ICU), the effect of RBC transfusion on long-term outcomes remains undetermined. We aimed to explore the association between RBC transfusion and the long-term prognosis of surgical sepsis survi...

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Bibliographic Details
Published in:The American journal of surgery 2024-11, Vol.237, p.115790, Article 115790
Main Authors: Ma, Huan, Li, Shuhe, Dou, Ruoxu, Lui, Ka Yin, Song, Xiaodong, Qian, Xiayan, Liang, Yujun, Guan, Xiangdong, Cai, Changjie
Format: Article
Language:English
Subjects:
Adult
Age
Aged
Blood products
Blood transfusion
China - epidemiology
Creatinine
Erythrocyte Transfusion
Erythrocytes
Female
Health risks
Hemoglobin
Hemoglobins - analysis
Hemoglobins - metabolism
Hospitals
Humans
Infections
Intensive Care Units - statistics & numerical data
Kidney diseases
Length of stay
Liver cirrhosis
Male
Matching
Middle Aged
Mortality
Mortality risk
Patients
Prognosis
Propensity Score
Red blood cell transfusion
Retrospective Studies
Risk factors
Sepsis
Sepsis - blood
Sepsis - mortality
Sepsis - therapy
Sepsis survivor
Statistical analysis
Surgical intensive care unit
Surgical sepsis
Survival
Survivors - statistics & numerical data
Transfusion
Ventilators
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Summary:Despite the fact that red blood cell (RBC) transfusion is commonly applied in surgical intensive care unit (ICU), the effect of RBC transfusion on long-term outcomes remains undetermined. We aimed to explore the association between RBC transfusion and the long-term prognosis of surgical sepsis survivors. This retrospective study was conducted on adult sepsis patients admitted to a tertiary surgical ICU center in China. Patients were divided into transfusion and non-transfusion groups based on the presence of RBC transfusion. Propensity score matching (PSM) and inverse probability of treatment weighting (IPTW)were performed to balance the potential confounders. A total of 1421 surgical sepsis survivors were enrolled, including 403 transfused patients and 1018 non-transfused patients. There was a significant difference in 1-year mortality between the two groups (23.1 ​% vs 12.7 ​%, HR: 1.539, 95 ​% confidence interval [CI]: 1.030–2.299, P ​
ISSN:0002-9610
1879-1883
1879-1883
DOI:10.1016/j.amjsurg.2024.115790