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Safety and efficacy of cryotherapy on chronic rhinitis: a systematic review and meta-analysis
Background Chronic rhinitis is when the nasal passages become inflamed and irritated, causing symptoms like nasal congestion, runny nose, sneezing, and postnasal drip that last for at least 12 weeks. While various medical treatments are available for chronic rhinitis, studies have shown that patient...
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| Published in: | European archives of oto-rhino-laryngology 2024-10, Vol.281 (10), p.5075-5089 |
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| creator | Alanazi, Farhan Alenezi, Mazyad Altimyat, Alwaleed Alanazy, Sultan |
| description | Background
Chronic rhinitis is when the nasal passages become inflamed and irritated, causing symptoms like nasal congestion, runny nose, sneezing, and postnasal drip that last for at least 12 weeks. While various medical treatments are available for chronic rhinitis, studies have shown that patients often do not comply with the treatment or report that it is ineffective. Cryotherapy for the nasal mucosa is a surgical option that has shown promise for these patients, with acceptable side effects.
Aim
Our goal is to evaluate the existing literature regarding the effectiveness and safety of cryotherapy as a treatment for chronic rhinitis.
Methods
We searched four electronic databases for relevant studies. Data were extracted from the included studies after screening procedures. Using the random effect model, we calculated the pooled mean difference (MD) for our continuous outcomes and pooled proportions for categorical outcomes. The I
2
test was used to detect heterogenicity. Randomized controlled trials (RCTs) were assessed for methodological quality using the Cochrane risk of bias assessment tool 2, while observational studies and single-arm studies were assessed using the National Institutes of Health's tools.
Results
Our study comprised 21 studies; eighteen were eligible for analysis, with 1663 patients with chronic rhinitis. All of our assessed outcomes showed improvement with cryotherapy from their baseline status. Our pooled MDs for Total Nasal Symptom Score (rTNSS), Rhinoconjunctivitis Quality of Life Questionnaire (RQLQ), and Nasal Obstruction Symptom Evaluation (NOSE) scores were as follows: ( − 3.58, 95% CI [ − 3.80, − 3.37], p |
| doi_str_mv | 10.1007/s00405-024-08754-2 |
| format | article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_3065985645</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>3065985645</sourcerecordid><originalsourceid>FETCH-LOGICAL-c228t-17982423911b679641074aca7c00fa67b1bb37850134a6bc0e4ddb5dc439bed23</originalsourceid><addsrcrecordid>eNp9kD1PwzAQQC0EoqXwBxhQRhbD2T7HCRuq-JIqMQAjshzHoa6apNgpKP-e9ANGJut8797wCDlncMUA1HUEQJAUOFLIlETKD8iYoUCKiqeHZAy5UBRRqRE5iXEBABJzcUxGIssQZcbH5P3FVK7rE9OUiasqb43tk7ZKbOjbbu6CWQ1jk9h5aBtvkzD3je98vElMEvvYudp0m2_35d33VlK7zlDTmGUffTwlR5VZRne2fyfk7f7udfpIZ88PT9PbGbWcZx1lKs84cpEzVqQqT5GBQmONsgCVSVXBikKoTAITaNLCgsOyLGRpUeSFK7mYkMuddxXaz7WLna59tG65NI1r11ELSGWeyRTlgPIdakMbY3CVXgVfm9BrBnqTVe-y6iGr3mbVG__F3r8ualf-nfx2HACxA-Kwaj5c0It2HYYK8T_tD5i6gx8</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>3065985645</pqid></control><display><type>article</type><title>Safety and efficacy of cryotherapy on chronic rhinitis: a systematic review and meta-analysis</title><source>Springer Nature</source><creator>Alanazi, Farhan ; Alenezi, Mazyad ; Altimyat, Alwaleed ; Alanazy, Sultan</creator><creatorcontrib>Alanazi, Farhan ; Alenezi, Mazyad ; Altimyat, Alwaleed ; Alanazy, Sultan</creatorcontrib><description>Background
Chronic rhinitis is when the nasal passages become inflamed and irritated, causing symptoms like nasal congestion, runny nose, sneezing, and postnasal drip that last for at least 12 weeks. While various medical treatments are available for chronic rhinitis, studies have shown that patients often do not comply with the treatment or report that it is ineffective. Cryotherapy for the nasal mucosa is a surgical option that has shown promise for these patients, with acceptable side effects.
Aim
Our goal is to evaluate the existing literature regarding the effectiveness and safety of cryotherapy as a treatment for chronic rhinitis.
Methods
We searched four electronic databases for relevant studies. Data were extracted from the included studies after screening procedures. Using the random effect model, we calculated the pooled mean difference (MD) for our continuous outcomes and pooled proportions for categorical outcomes. The I
2
test was used to detect heterogenicity. Randomized controlled trials (RCTs) were assessed for methodological quality using the Cochrane risk of bias assessment tool 2, while observational studies and single-arm studies were assessed using the National Institutes of Health's tools.
Results
Our study comprised 21 studies; eighteen were eligible for analysis, with 1663 patients with chronic rhinitis. All of our assessed outcomes showed improvement with cryotherapy from their baseline status. Our pooled MDs for Total Nasal Symptom Score (rTNSS), Rhinoconjunctivitis Quality of Life Questionnaire (RQLQ), and Nasal Obstruction Symptom Evaluation (NOSE) scores were as follows: ( − 3.58, 95% CI [ − 3.80, − 3.37], p < 0.001), ( − 1.48, 95% CI [ − 1.68, − 1.27], p < 0.001), and ( − 26.65, 95% CI [ − 33.98, − 19.31], p < 0.001), respectively. Regarding nasal obstruction and rhinorrhea, cryotherapy showed effectiveness in 61% and 52% of patients in the complete relief subgroup and 26% and 34% in the < 50%-relief subgroup, respectively.
Conclusion
We observed significant improvement in our measured outcomes as rTNSS, RQLQ, and NOSE scores compared to the baseline state, demonstrating the cryotherapy's efficacy. This improvement was consistent in all subsequent follow-up periods. However, we need more high-quality RCTs for stronger evidence to be generalized.</description><identifier>ISSN: 0937-4477</identifier><identifier>ISSN: 1434-4726</identifier><identifier>EISSN: 1434-4726</identifier><identifier>DOI: 10.1007/s00405-024-08754-2</identifier><identifier>PMID: 38844582</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Head and Neck Surgery ; Medicine ; Medicine & Public Health ; Neurosurgery ; Otorhinolaryngology ; Review Article</subject><ispartof>European archives of oto-rhino-laryngology, 2024-10, Vol.281 (10), p.5075-5089</ispartof><rights>The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2024. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.</rights><rights>2024. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c228t-17982423911b679641074aca7c00fa67b1bb37850134a6bc0e4ddb5dc439bed23</cites><orcidid>0000-0002-2153-3055</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27903,27904</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38844582$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Alanazi, Farhan</creatorcontrib><creatorcontrib>Alenezi, Mazyad</creatorcontrib><creatorcontrib>Altimyat, Alwaleed</creatorcontrib><creatorcontrib>Alanazy, Sultan</creatorcontrib><title>Safety and efficacy of cryotherapy on chronic rhinitis: a systematic review and meta-analysis</title><title>European archives of oto-rhino-laryngology</title><addtitle>Eur Arch Otorhinolaryngol</addtitle><addtitle>Eur Arch Otorhinolaryngol</addtitle><description>Background
Chronic rhinitis is when the nasal passages become inflamed and irritated, causing symptoms like nasal congestion, runny nose, sneezing, and postnasal drip that last for at least 12 weeks. While various medical treatments are available for chronic rhinitis, studies have shown that patients often do not comply with the treatment or report that it is ineffective. Cryotherapy for the nasal mucosa is a surgical option that has shown promise for these patients, with acceptable side effects.
Aim
Our goal is to evaluate the existing literature regarding the effectiveness and safety of cryotherapy as a treatment for chronic rhinitis.
Methods
We searched four electronic databases for relevant studies. Data were extracted from the included studies after screening procedures. Using the random effect model, we calculated the pooled mean difference (MD) for our continuous outcomes and pooled proportions for categorical outcomes. The I
2
test was used to detect heterogenicity. Randomized controlled trials (RCTs) were assessed for methodological quality using the Cochrane risk of bias assessment tool 2, while observational studies and single-arm studies were assessed using the National Institutes of Health's tools.
Results
Our study comprised 21 studies; eighteen were eligible for analysis, with 1663 patients with chronic rhinitis. All of our assessed outcomes showed improvement with cryotherapy from their baseline status. Our pooled MDs for Total Nasal Symptom Score (rTNSS), Rhinoconjunctivitis Quality of Life Questionnaire (RQLQ), and Nasal Obstruction Symptom Evaluation (NOSE) scores were as follows: ( − 3.58, 95% CI [ − 3.80, − 3.37], p < 0.001), ( − 1.48, 95% CI [ − 1.68, − 1.27], p < 0.001), and ( − 26.65, 95% CI [ − 33.98, − 19.31], p < 0.001), respectively. Regarding nasal obstruction and rhinorrhea, cryotherapy showed effectiveness in 61% and 52% of patients in the complete relief subgroup and 26% and 34% in the < 50%-relief subgroup, respectively.
Conclusion
We observed significant improvement in our measured outcomes as rTNSS, RQLQ, and NOSE scores compared to the baseline state, demonstrating the cryotherapy's efficacy. This improvement was consistent in all subsequent follow-up periods. However, we need more high-quality RCTs for stronger evidence to be generalized.</description><subject>Head and Neck Surgery</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Neurosurgery</subject><subject>Otorhinolaryngology</subject><subject>Review Article</subject><issn>0937-4477</issn><issn>1434-4726</issn><issn>1434-4726</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><recordid>eNp9kD1PwzAQQC0EoqXwBxhQRhbD2T7HCRuq-JIqMQAjshzHoa6apNgpKP-e9ANGJut8797wCDlncMUA1HUEQJAUOFLIlETKD8iYoUCKiqeHZAy5UBRRqRE5iXEBABJzcUxGIssQZcbH5P3FVK7rE9OUiasqb43tk7ZKbOjbbu6CWQ1jk9h5aBtvkzD3je98vElMEvvYudp0m2_35d33VlK7zlDTmGUffTwlR5VZRne2fyfk7f7udfpIZ88PT9PbGbWcZx1lKs84cpEzVqQqT5GBQmONsgCVSVXBikKoTAITaNLCgsOyLGRpUeSFK7mYkMuddxXaz7WLna59tG65NI1r11ELSGWeyRTlgPIdakMbY3CVXgVfm9BrBnqTVe-y6iGr3mbVG__F3r8ualf-nfx2HACxA-Kwaj5c0It2HYYK8T_tD5i6gx8</recordid><startdate>20241001</startdate><enddate>20241001</enddate><creator>Alanazi, Farhan</creator><creator>Alenezi, Mazyad</creator><creator>Altimyat, Alwaleed</creator><creator>Alanazy, Sultan</creator><general>Springer Berlin Heidelberg</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-2153-3055</orcidid></search><sort><creationdate>20241001</creationdate><title>Safety and efficacy of cryotherapy on chronic rhinitis: a systematic review and meta-analysis</title><author>Alanazi, Farhan ; Alenezi, Mazyad ; Altimyat, Alwaleed ; Alanazy, Sultan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c228t-17982423911b679641074aca7c00fa67b1bb37850134a6bc0e4ddb5dc439bed23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Head and Neck Surgery</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Neurosurgery</topic><topic>Otorhinolaryngology</topic><topic>Review Article</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Alanazi, Farhan</creatorcontrib><creatorcontrib>Alenezi, Mazyad</creatorcontrib><creatorcontrib>Altimyat, Alwaleed</creatorcontrib><creatorcontrib>Alanazy, Sultan</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>European archives of oto-rhino-laryngology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Alanazi, Farhan</au><au>Alenezi, Mazyad</au><au>Altimyat, Alwaleed</au><au>Alanazy, Sultan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Safety and efficacy of cryotherapy on chronic rhinitis: a systematic review and meta-analysis</atitle><jtitle>European archives of oto-rhino-laryngology</jtitle><stitle>Eur Arch Otorhinolaryngol</stitle><addtitle>Eur Arch Otorhinolaryngol</addtitle><date>2024-10-01</date><risdate>2024</risdate><volume>281</volume><issue>10</issue><spage>5075</spage><epage>5089</epage><pages>5075-5089</pages><issn>0937-4477</issn><issn>1434-4726</issn><eissn>1434-4726</eissn><abstract>Background
Chronic rhinitis is when the nasal passages become inflamed and irritated, causing symptoms like nasal congestion, runny nose, sneezing, and postnasal drip that last for at least 12 weeks. While various medical treatments are available for chronic rhinitis, studies have shown that patients often do not comply with the treatment or report that it is ineffective. Cryotherapy for the nasal mucosa is a surgical option that has shown promise for these patients, with acceptable side effects.
Aim
Our goal is to evaluate the existing literature regarding the effectiveness and safety of cryotherapy as a treatment for chronic rhinitis.
Methods
We searched four electronic databases for relevant studies. Data were extracted from the included studies after screening procedures. Using the random effect model, we calculated the pooled mean difference (MD) for our continuous outcomes and pooled proportions for categorical outcomes. The I
2
test was used to detect heterogenicity. Randomized controlled trials (RCTs) were assessed for methodological quality using the Cochrane risk of bias assessment tool 2, while observational studies and single-arm studies were assessed using the National Institutes of Health's tools.
Results
Our study comprised 21 studies; eighteen were eligible for analysis, with 1663 patients with chronic rhinitis. All of our assessed outcomes showed improvement with cryotherapy from their baseline status. Our pooled MDs for Total Nasal Symptom Score (rTNSS), Rhinoconjunctivitis Quality of Life Questionnaire (RQLQ), and Nasal Obstruction Symptom Evaluation (NOSE) scores were as follows: ( − 3.58, 95% CI [ − 3.80, − 3.37], p < 0.001), ( − 1.48, 95% CI [ − 1.68, − 1.27], p < 0.001), and ( − 26.65, 95% CI [ − 33.98, − 19.31], p < 0.001), respectively. Regarding nasal obstruction and rhinorrhea, cryotherapy showed effectiveness in 61% and 52% of patients in the complete relief subgroup and 26% and 34% in the < 50%-relief subgroup, respectively.
Conclusion
We observed significant improvement in our measured outcomes as rTNSS, RQLQ, and NOSE scores compared to the baseline state, demonstrating the cryotherapy's efficacy. This improvement was consistent in all subsequent follow-up periods. However, we need more high-quality RCTs for stronger evidence to be generalized.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>38844582</pmid><doi>10.1007/s00405-024-08754-2</doi><tpages>15</tpages><orcidid>https://orcid.org/0000-0002-2153-3055</orcidid></addata></record> |
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| subjects | Head and Neck Surgery Medicine Medicine & Public Health Neurosurgery Otorhinolaryngology Review Article |
| title | Safety and efficacy of cryotherapy on chronic rhinitis: a systematic review and meta-analysis |
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