Soluble adhesion molecules: Cognitive worsening biomarkers in primary progressive multiple sclerosis?

[Display omitted] •Soluble adhesion markers may represent cognitive biomarkers in multiple sclerosis•Soluble NCAM-1 and VCAM-1 are elevated in primary progressive multiple sclerosis•Cognitive worsening in PPMS is associated with higher baseline VCAM-1 levels•Each 100 ng/mL VCAM-1 increase carries a...

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Bibliographic Details
Published in:Journal of neuroimmunology 2024-08, Vol.393, p.578384, Article 578384
Main Authors: Yong, Heather Y.F., Batty, Nicholas J., Tottenham, Isabelle, Koch, Marcus, Camara-Lemarroy, Carlos R.
Format: Article
Language:English
Subjects:
Cognition
Multiple sclerosis
Primary progressive multiple sclerosis
Soluble adhesion markers
Soluble vascular cell adhesion molecule-1
Symbol digit modalities test
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Summary:[Display omitted] •Soluble adhesion markers may represent cognitive biomarkers in multiple sclerosis•Soluble NCAM-1 and VCAM-1 are elevated in primary progressive multiple sclerosis•Cognitive worsening in PPMS is associated with higher baseline VCAM-1 levels•Each 100 ng/mL VCAM-1 increase carries a 30% increased odds of cognitive worsening•Lower baseline BDNF is associated with lower baseline cognitive scores in PPMS
ISSN:0165-5728
1872-8421
1872-8421
DOI:10.1016/j.jneuroim.2024.578384