Radiation-induced sarcoma in patients with nasopharyngeal carcinoma: a single-institution retrospective study

• Published in: Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology, head, and neck surgery head, and neck surgery, 2024-06, Vol.38 (6), p.514
• Main Authors: Xie, Sifang, Zhang, Jintao, Qin, Yangda, Li, Min, Lan, Guiping, Wang, Yongli, Huang, Bo, Weng, Jingjin, Wei, Jiazhang, Qu, Shenhong
• Format: Article
• Language: Chinese
• Subjects: Adolescent; Adult; Child; Child, Preschool; Female; Head and Neck Neoplasms - etiology; Humans; Male; Nasopharyngeal Carcinoma - radiotherapy; Nasopharyngeal Neoplasms - radiotherapy; Neoplasms, Radiation-Induced; Prognosis; Retrospective Studies; Sarcoma - etiology; Treatment Outcome
• ISSN: 2096-7993
• DOI: 10.13201/j.issn.2096-7993.2024.06.011

To analyze the clinical features, treatment methods and prognosis of radiation-induced sarcoma（RIS） of the head and neck after radiotherapy for nasopharyngeal carcinoma（NPC）, and explore its treatment strategies. A retrospective analysis was conducted on RIS patients after radiotherapy for NPC in the People's Hospital of Guangxi Zhuang Autonomous Region from January 2013 to October 2022. The time of onset, lesion location, pathological subtypes, imaging features and treatment outcomes were described, and the median survival time was statistically analyzed through follow-up. This study included 10 patients with an interval of 2-27 years between NPC and RIS. The nasopharynx was the more common site of RIS, and osteosarcoma was the main pathological type. The median overall survival was 18 months. The median survival was 40 months in the surgery combined with the chemotherapy group, and 12 months in the surgery alone group. The 1-and 2-year cumulative survival rates were 48% and 36%, respectively. Prognostic ana