The Effectiveness and Safety of Leadless Pacemakers: An Updated Meta-Analysis

Background Leadless pacemakers (LPs) are promising alternatives to traditional transvenous pacemakers (TVPs), but their comparative effectiveness and safety in clinical outcomes remain uncertain. Methods We systematically searched PubMed, Embase, Scopus, Cochrane, and ClinicalTrials.gov for studies...

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Bibliographic Details
Published in:Current cardiology reports 2024-08, Vol.26 (8), p.789-799
Main Authors: Oliveira, Vinícius Martins Rodrigues, Rivera, André, Oliveira, Izadora Caiado, de Sousa, André Maroccolo, Nishikubo, Maria Elisa Passos, Serpa, Frans, da Silva Menezes Junior, Antônio
Format: Article
Language:English
Subjects:
Cardiology
Invasive Electrophysiology and Pacing (EK Heist and S Nedios
Medicine
Medicine & Public Health
Section Editors
Topical Collection on Invasive Electrophysiology and Pacing
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Summary:Background Leadless pacemakers (LPs) are promising alternatives to traditional transvenous pacemakers (TVPs), but their comparative effectiveness and safety in clinical outcomes remain uncertain. Methods We systematically searched PubMed, Embase, Scopus, Cochrane, and ClinicalTrials.gov for studies comparing LPs and TVPs. A restricted maximum likelihood random-effects model was used for all outcomes. Heterogeneity was assessed using I 2 statistics. We performed a subgroup analysis with studies with multivariate-adjusted data. Results We included 21 studies involving 47,229 patients, of whom 12,199 (25.8%) underwent LP implantation. Compared with TVPs, LPs were associated with a significantly lower risk of overall complications (OR 0.61; 95% CI 0.45–0.81; p  
ISSN:1523-3782
1534-3170
1534-3170
DOI:10.1007/s11886-024-02079-6