Structure and in vitro antiproliferative activity against breast cancer cells of the cell-wall polysaccharide from the marine bacterium Kangiella japonica KMM 3899T

Kangiella japonica KMM 3899T is a Gram-negative bacterium isolated from a sandy sediment sample collected from the Sea of Japan. Here the results of the structure and the biological activity against breast cancer cells of the cell-wall polysaccharide from K. japonica KMM 3899T have been described. T...

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Bibliographic Details
Published in:Carbohydrate polymers 2024-10, Vol.341, p.122360, Article 122360
Main Authors: Kokoulin, Maxim S., Kuzmich, Alexandra S., Romanenko, Lyudmila A.
Format: Article
Language:English
Subjects:
Antiproliferative activity
Breast cancer
Kangiella japonica
Marine bacterium
Polysaccharide
Online Access:Get full text
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Summary:Kangiella japonica KMM 3899T is a Gram-negative bacterium isolated from a sandy sediment sample collected from the Sea of Japan. Here the results of the structure and the biological activity against breast cancer cells of the cell-wall polysaccharide from K. japonica KMM 3899T have been described. The structure of the repeating unit of the polysaccharide was elucidated using chemical analysis and NMR spectroscopy: →4)-α-L-GalpNAc3AcA-(1 → 3)-α-D-GlcpNAc-(1 → 4)-β-D-GlcpNAc3NAcAN-(1→. The cell-wall polysaccharide had an antiproliferative effect against T-47D cells. Flow cytometric and Western blot analysis revealed that the polysaccharide induced S phase arrest and mitochondrial-dependent apoptosis. [Display omitted]
ISSN:0144-8617
1879-1344
1879-1344
DOI:10.1016/j.carbpol.2024.122360