Understanding the HPV associated cancers: A comprehensive review

Human papillomavirus (HPV), a common cause of sexually transmitted diseases, may cause warts and lead to various types of cancers, which makes it important to understand the risk factors associated with it. HPV is the leading risk factor and plays a crucial role in the progression of cervical cancer...

Full description

Saved in:
Bibliographic Details
Published in:Molecular biology reports 2024-12, Vol.51 (1), p.743-743
Main Authors: Balhara, Nikita, Yadav, Ritu, Ranga, Shalu, Ahuja, Parul, Tanwar, Mukesh
Format: Article
Language:English
Subjects:
Animal Anatomy
Animal Biochemistry
Apoptosis
Biomedical and Life Sciences
Carcinogens
Cell cycle
Cell growth
Cervical cancer
DNA methylation
Epigenetics
Female
Genomes
Growth factors
Heparan sulfate
Histology
Human papillomavirus
Humans
Immune system
Immunotherapy
Infections
Life Sciences
Male
Malignancy
Molecular biology
Morphology
Neoplasms - therapy
Neoplasms - virology
Oncogene Proteins, Viral - genetics
Oncogene Proteins, Viral - metabolism
Papillomaviridae - pathogenicity
Papillomavirus Infections - complications
Papillomavirus Infections - virology
Penis
Proteins
Review
Risk Factors
Sexually transmitted diseases
STD
Uterine Cervical Neoplasms - etiology
Uterine Cervical Neoplasms - virology
Vaccination
Vagina
Warts
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Human papillomavirus (HPV), a common cause of sexually transmitted diseases, may cause warts and lead to various types of cancers, which makes it important to understand the risk factors associated with it. HPV is the leading risk factor and plays a crucial role in the progression of cervical cancer. Viral oncoproteins E6 and E7 play a pivotal role in this process. Beyond cervical cancer, HPV-associated cancers of the mouth and throat are also increasing. HPV can also contribute to other malignancies like penile, vulvar, and vaginal cancers. Emerging evidence links HPV to these cancers. Research on the oncogenic effect of HPV is still ongoing and explorations of screening techniques, vaccination, immunotherapy and targeted therapeutics are all in progress. The present review offers valuable insight into the current understanding of the role of HPV in cancer and its potential implications for treatment and prevention in the future.
ISSN:0301-4851
1573-4978
DOI:10.1007/s11033-024-09680-6