Isolation and Genomic Characterization of Schaalia turicensis from a Patient with Gonococcal Urethritis, Thailand

Schaalia turicensis is facultative anaerobic Gram-positive bacillus that commonly inhabits the oropharynx, gastrointestinal, and genitourinary tract of healthy individuals. This organism has been co-isolated with Neisseria gonorrhoeae from 15-year-old Thai male patient with gonococcal urethritis in...

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Bibliographic Details
Published in:Current microbiology 2024-08, Vol.81 (8), p.221, Article 221
Main Authors: Nokchan, Natakorn, Wongsurawat, Thidathip, Jenjaroenpun, Piroon, Nitayanon, Perapon, Saechan, Charinrat, Thirakittiwatthana, Witoon, Tribuddharat, Chanwit
Format: Article
Language:English
Subjects:
Adolescent
Aminoglycosides
Anti-Bacterial Agents - pharmacology
Antimicrobial agents
Bioinformatics
Biomedical and Life Sciences
Biotechnology
Chloramphenicol
Chloromycetin
DNA Transposable Elements - genetics
Drug resistance
Drug Resistance, Bacterial - genetics
Gene sequencing
Genes
Genitourinary tract
Genome, Bacterial
Genomes
Genomic analysis
Gonorrhea
Gonorrhea - microbiology
Gram-positive bacilli
Humans
Life Sciences
Male
Medical technology
Microbial Sensitivity Tests
Microbiology
Neisseria gonorrhoeae - classification
Neisseria gonorrhoeae - drug effects
Neisseria gonorrhoeae - genetics
Neisseria gonorrhoeae - isolation & purification
Oropharynx
Pathogens
Proteins
Quality control
Schaalia
Short Communication
Sulfonamides
Thailand
Transposons
Urethritis
Urethritis - microbiology
Whole Genome Sequencing
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Summary:Schaalia turicensis is facultative anaerobic Gram-positive bacillus that commonly inhabits the oropharynx, gastrointestinal, and genitourinary tract of healthy individuals. This organism has been co-isolated with Neisseria gonorrhoeae from 15-year-old Thai male patient with gonococcal urethritis in Bangkok, Thailand. In this study, we characterized the class 1 integron in S. turicensis isolate using whole-genome sequencing and bioinformatics analysis. Sequencing analysis confirmed the presence of an imperfect class 1 integron located on chromosome and a novel 24.5-kb-long composite transposon, named Tn 7083 . The transposon Tn 7083 carried genes encoding chloramphenicol resistance ( cmx ), sulfonamide resistance ( sul1 ), and aminoglycoside resistance [ aph ( 6 )- Id ( strB ), aph ( 3ʹʹ )- Ib ( strA ), aph ( 3ʹ )- Ia ].
ISSN:0343-8651
1432-0991
1432-0991
DOI:10.1007/s00284-024-03756-z