Spectral CT for preoperative diagnosis of N2 station lymph node metastasis in solid T1 non-small cell lung cancer

• Published in: European journal of radiology 2024-08, Vol.177, p.111553, Article 111553
• Main Authors: Zhu, Guanbin, Wang, Jin-an, Xiao, Dongjian, Guo, Xiaoxi, Huang, Yimin, Guo, Luxin, Li, Minjie, Wu, Huita, Zhang, Yongjun, Wang, Yong
• Format: Article
• Language: English
• Subjects: Computed tomography; Lymph node metastasis; Non-small cell lung cancer; Spectral CT
• ISSN: 0720-048X; 1872-7727; 1872-7727
• DOI: 10.1016/j.ejrad.2024.111553

•Spectral CT improved radiologists’ performance in lymph node staging of solid T1 non-small cell lung cancer (NSCLC).•The spectral parameters were significant different between metastatic and non-metastatic lymph nodes.•Spectral CT could provide great help in the preoperative diagnosis of N2 station lymph nodes metastasis and treatment in solid T1 NSCLC. To evaluate the diagnostic value of spectral CT for the preoperative diagnosis of N2 station lymph nodes metastasis in solid T1 non-small cell lung cancer (NSCLC). For this retrospective study, dual-phase contrast agent-enhanced CT was performed in patients with NSCLC from September 2019 to June 2023. Quantitative spectral CT parameters measurements were performed by 2 radiologists independently. Logistic regression analysis and Delong test were performed. 60 NSCLC patients (mean age, 62.85 years ± 8.49, 44men) were evaluated. A total of 121 lymph nodes (38 with metastasis) were enrolled. There was no significant difference in the slope of the spectral Hounsfield unit curve (λHu) on arterial phase (AP) or venous phase (VP) between primary lesions and metastatic lymph nodes (P > 0.05), but significant difference in VP λHu between primary lesions and non-metastatic lymph nodes (P