Hippo signaling modulation and its biological implications in urological malignancies

Although cancer diagnosis and treatment have rapidly advanced in recent decades, urological malignancies, which have high morbidity and mortality rates, are among the most difficult diseases to treat. The Hippo signaling is an evolutionarily conserved pathway in organ size control and tissue homeost...

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Bibliographic Details
Published in:Molecular aspects of medicine 2024-08, Vol.98, p.101280, Article 101280
Main Authors: Tong, Tongyu, Huang, Mengjun, Yan, Binyuan, Lin, Bingbiao, Yu, Jiaying, Teng, Qiliang, Li, Peng, Pang, Jun
Format: Article
Language:English
Subjects:
Adaptor Proteins, Signal Transducing - metabolism
Animals
Bladder cancer
Gene Expression Regulation, Neoplastic
Hippo signaling
Hippo Signaling Pathway
Humans
Kidney cancer
Male
Prostate cancer
Protein Serine-Threonine Kinases - metabolism
Signal Transduction
Transcription Factors - metabolism
Transcriptional Coactivator with PDZ-Binding Motif Proteins - metabolism
Transcriptional regulation
Urinary Bladder Neoplasms - genetics
Urinary Bladder Neoplasms - metabolism
Urinary Bladder Neoplasms - pathology
Urologic Neoplasms - etiology
Urologic Neoplasms - metabolism
Urologic Neoplasms - pathology
YAP-Signaling Proteins - metabolism
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Summary:Although cancer diagnosis and treatment have rapidly advanced in recent decades, urological malignancies, which have high morbidity and mortality rates, are among the most difficult diseases to treat. The Hippo signaling is an evolutionarily conserved pathway in organ size control and tissue homeostasis maintenance. Its downstream effectors, Yes-associated protein (YAP) and transcriptional coactivator with PDZ-binding motif (TAZ), are key modulators of numerous physiological and pathological processes. Recent work clearly indicates that Hippo signaling is frequently altered in human urological malignancies. In this review, we discuss the disparate viewpoints on the upstream regulators of YAP/TAZ and their downstream targets and systematically summarize the biological implications. More importantly, we highlight the molecular mechanisms involved in Hippo-YAP signaling to improve our understanding of its role in every stage of prostate cancer, bladder cancer and kidney cancer progression. A better understanding of the biological outcomes of YAP/TAZ modulation will contribute to the establishment of future therapeutic approaches.
ISSN:0098-2997
1872-9452
1872-9452
DOI:10.1016/j.mam.2024.101280