Polycystic ovary syndrome: Insights into its prevalence, diagnosis, and management with special reference to gut microbial dysbiosis

• Published in: Steroids 2024-08, Vol.208, p.109455, Article 109455
• Main Authors: Khobragade, Nisha H., Sheth, Devang B., Patel, Chirag A., Beladiya, Jayesh V., Patel, Sandip, Dalal, Mittal
• Format: Article
• Language: English
• Subjects: Microbial dysbiosis; Pathogenesis of PCOS and gut dysbiosis; Polycystic ovary syndrome; Prevalence’s rate; Treatment
• ISSN: 0039-128X; 1878-5867; 1878-5867
• DOI: 10.1016/j.steroids.2024.109455

[Display omitted] •The review provides a thorough overview of Polycystic Ovary Syndrome (PCOS), including its pathogenesis, clinical features and diagnostic criteria.•It covers various reports stating prevalence rate of PCOS in India.•The framework aims to help readers to understand the connection between microbial dysbiosis and the development of PCOS.•It gives insight into traditional and novel management strategies for treating microbial dysbiosis with special emphasis to PCOS. Polycystic ovary syndrome (PCOS) represents major endocrine and metabolic disorder among women largely characterized by hyperandrogenism and oligomenorrhea precipitates serious complications such as type 2 diabetes, early atherosclerosis, infertility, and endometrial cancer. Several etiological theories were proposed to define the exact cause of the PCOS, which is characterized, by the hypothalamic-pituitary axis, ovarian morphology, and release of adrenal steroid hormones, metabolic syndrome, and hereditary factors. The review explored the role of dysbiosis and the mechanisms through which microbial dysbiosis can affect PCOS development. In recent time, various research groups highlighted the role of microbial gut dysbiosis associated with obesity as potential etiological factor for the PCOS. In the present review, we reviewed the mechanisms attributed to the microbial dysbiosis and treatment approaches to deal with the situation.