Docosahexaenoic acid, eicosapentaenoic acid, arachidonic acid, and neural tube defects in Tunisian population

• Published in: Birth defects research 2024-06, Vol.116 (6), p.e2372-n/a
• Main Authors: Nasri, Kaouther, Ben Jamaa, Nadia, Siala Gaigi, Soumeya, Feki, Moncef, Marrakchi, Raja
• Format: Article
• Language: English
• Subjects: Acids; Adult; Arachidonic acid; Arachidonic Acid - blood; Arachidonic Acid - metabolism; Birth defects; Blood levels; Calciferol; Case-Control Studies; Cyanocobalamin; Defects; Docosahexaenoic acid; Docosahexaenoic Acids - blood; Eicosapentaenoic acid; Eicosapentaenoic Acid - blood; Erythrocytes; Female; Folic acid; Folic Acid - blood; Gas chromatography; genetic polymorphisms; Genotype; Genotypes; Homocysteine; Homocysteine - blood; Homocysteine - genetics; Humans; Methylenetetrahydrofolate reductase; Methylenetetrahydrofolate Reductase (NADPH2) - genetics; Neural tube defects; Neural Tube Defects - genetics; Plasma; Pregnancy; Tunisia; Vitamin B; Vitamin B 12 - blood; Vitamin B12; Vitamin D; Vitamin D - blood; Vitamin D - genetics
• ISSN: 2472-1727; 2472-1727
• DOI: 10.1002/bdr2.2372

Objective To determine the effect of maternal status in (plasma and red blood cell) folate, vitamin B12, homocysteine, and vitamin D, as well as their interaction with MTHFR (C677T and A1298C) and MTRR A66G polymorphisms, on maternal plasma docosahexaenoic acid (DHA), eicosapentaenoic acid (EPA), and arachidonic acid (ARA) levels and the risk of neural tube defects (NTDs). Methods ARA, EPA, and DHA composition was assessed using capillary gas chromatography. Results ARA and DHA levels were higher in controls than in case mothers for low plasma folate status. For low red blood cell folate status, DHA levels were higher in controls than in case mothers. For high homocysteine levels, ARA and DHA levels were higher in controls than in case mothers. NTD mothers had lower EPA and DHA levels for low vitamin B12 levels. NTD mothers had lower DHA levels for low vitamin D levels. For low plasma folate status, DHA levels in the MTHFR C677T gene and ARA and EPA levels in MTHFR A1298C gene were different among the three genotypes in case mothers. DHA levels in the MTHFR C677T gene were different among the three genotypes in case mothers for both low and high homocysteine levels. For low vitamin B12 levels, ARA and DHA levels were different among the three genotypes of the MTHFR C677T gene in case mothers. In the MTHFR C677T gene, ARA and DHA levels were different among the three genotypes in case mothers for low vitamin D levels. Conclusions More advanced research is required to verify a suitable biochemical parameter status in relation to the genotypes in pregnant women.