Extracellular vesicles: Illuminating renal pathophysiology and therapeutic frontiers

Extracellular vesicles (EVs) are minute sacs released by cells into the extracellular milieu, harboring an array of biomolecules including proteins, nucleic acids, and lipids. Notably, a large number of studies have demonstrated the important involvement of EVs in both physiological and pathological...

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Bibliographic Details
Published in:European journal of pharmacology 2024-09, Vol.978, p.176720, Article 176720
Main Authors: Shi, Linru, Zeng, Houcheng, An, Zhongwu, Chen, Wenya, Shan, Yunjie, Ji, Cheng, Qian, Hui
Format: Article
Language:English
Subjects:
Biomarker
Extracellular vesicles
Kidney disease
Therapy
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Summary:Extracellular vesicles (EVs) are minute sacs released by cells into the extracellular milieu, harboring an array of biomolecules including proteins, nucleic acids, and lipids. Notably, a large number of studies have demonstrated the important involvement of EVs in both physiological and pathological aspects of renal function. EVs can facilitate communication between different renal cells, but it is important to recognize their dual role: they can either transmit beneficial information or lead to renal damage and worsening of existing conditions. The composition of EVs in the context of the kidneys offers valuable insights into the intricate mechanisms underlying specific renal functions or disease states. In addition, mesenchymal stem cell-derived EVs have the potential to alleviate acute and chronic kidney diseases. More importantly, the innate nanoparticle properties of EVs, coupled with their engineering potential, make them effective tools for drug delivery and therapeutic intervention. In this review, we focus on the intricate biological functions of EVs in the kidney. In addition, we explore the emerging role of EVs as diagnostic tools and innovative therapeutic agents in a range of renal diseases. [Display omitted] •Extracellular vesicles in kidney transmit beneficial signals but can also cause damage.•Active substances in extracellular vesicles can be used to diagnose kidney disease.•Mesenchymal stem cell-derived extracellular vesicles possess the capacity to foster renal repair.•Engineered extracellular vesicles enhance therapeutic interventions for kidney disease.
ISSN:0014-2999
1879-0712
1879-0712
DOI:10.1016/j.ejphar.2024.176720