Prenatal exposure to polycyclic aromatic hydrocarbons and executive functions at school age: Results from a combined cohort study

• Published in: International journal of hygiene and environmental health 2024-07, Vol.260, p.114407, Article 114407
• Main Authors: Ni, Yu, Szpiro, Adam A., Loftus, Christine T., Workman, Tomomi, Sullivan, Alexis, Wallace, Erin R., Riederer, Anne M., Day, Drew B., Murphy, Laura E., Nguyen, Ruby H.N., Sathyanarayana, Sheela, Barrett, Emily S., Zhao, Qi, Enquobahrie, Daniel A., Simpson, Christopher, Ahmad, Shaikh I., Arizaga, Jessica A., Collett, Brent R., Derefinko, Karen J., Kannan, Kurunthachalam, Bush, Nicole R., LeWinn, Kaja Z., Karr, Catherine J.
• Format: Article
• Language: English
• Subjects: Adult; Child; Cohort Studies; Environmental Pollutants - urine; Executive Function - drug effects; Executive functions; Female; Humans; Male; Maternal Exposure; Maternal psychosocial stress; Memory, Short-Term - drug effects; Mixture analysis; Polycyclic aromatic hydrocarbons; Polycyclic Aromatic Hydrocarbons - urine; Pregnancy; Prenatal Exposure Delayed Effects
• ISSN: 1438-4639; 1618-131X; 1618-131X
• DOI: 10.1016/j.ijheh.2024.114407

Executive functions develop rapidly in childhood, enabling problem-solving, focused attention, and planning. Exposures to environmental toxicants in pregnancy may impair healthy executive function development in children. There is increasing concern regarding polycyclic aromatic hydrocarbons (PAHs) given their ability to transfer across the placenta and the fetal blood-brain barrier, yet evidence from epidemiological studies is limited. We examined associations between prenatal PAH exposure and executive functions in 814 children of non-smoking mothers from two U.S. cohorts in the ECHO-PATHWAYS Consortium. Seven mono-hydroxylated PAH metabolites were measured in mid-pregnancy urine and analyzed individually and as mixtures. Three executive function domains were measured at age 8–9: cognitive flexibility, working memory, and inhibitory control. A composite score quantifying overall performance was further calculated. We fitted linear regressions adjusted for socio-demographics, maternal health behaviors, and psychological measures, and examined modification by child sex and stressful life events in pregnancy. Bayesian kernel machine regression was performed to estimate the interactive and overall effects of the PAH mixture. The results from primary analysis of linear regressions were generally null, and no modification by child sex or maternal stress was indicated. Mixture analyses suggested several pairwise interactions between individual PAH metabolites in varied directions on working memory, particularly interactions between 2/3/9-FLUO and other PAH metabolites, but no overall or individual effects were evident. We conducted a novel exploration of PAH-executive functions association in a large, combined sample from two cohorts. Although findings were predominantly null, the study carries important implications for future research and contributes to evolving science regarding developmental origins of diseases. •The PAH-executive functions associations were predominantly null.•Evidence suggested pairwise interactions between PAH metabolites on working memory.•Results did not support the “double jeopardy” of PAHs and maternal stress on executive functions.