Feasibility of a clinic-based, multicomponent hydroxyurea adherence intervention for adolescents and young adults with sickle cell disease

Despite the effectiveness of hydroxyurea, adherence remains low for adolescents and young adults (AYA) living with sickle cell disease (SCD). This study evaluated the feasibility, acceptability, and initial efficacy of a clinic-based, multicomponent (e.g., storytelling, problem solving) intervention...

Full description

Saved in:
Bibliographic Details
Published in:Pediatric blood & cancer 2024-09, Vol.71 (9), p.e31144
Main Authors: Murphy, Bridget N, Keenan-Pfeiffer, Mary E, Lane, Adam, Crosby, Lori E, Walsh, Kathleen E
Format: Article
Language:English
Subjects:
Adolescents
Feasibility studies
Hydroxyurea
Problem solving
Sickle cell disease
Young adults
Citations: Items that this one cites
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Despite the effectiveness of hydroxyurea, adherence remains low for adolescents and young adults (AYA) living with sickle cell disease (SCD). This study evaluated the feasibility, acceptability, and initial efficacy of a clinic-based, multicomponent (e.g., storytelling, problem solving) intervention with 20 AYA living with SCD. Results found that adherence significantly improved from intervention to follow-up 1 [t(19) = -2.213, p = .039]. AYA also were generally satisfied with the intervention. These findings, although promising, should be replicated on a larger scale.
ISSN:1545-5009
1545-5017
1545-5017
DOI:10.1002/pbc.31144