Development and characterization of an emulgel based on a snail slime useful for dermatological applications

[Display omitted] Snail slime is an interesting material for effective dermatological use (e.g. wounds). Its properties are stricly connected to the origin. In this paper a snail slime, deriving from the species Helix aspersa Muller and obtained from a company, was deeply characterized and then prop...

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Bibliographic Details
Published in:International journal of pharmaceutics 2024-07, Vol.660, p.124337, Article 124337
Main Authors: Pagano, Cinzia, Ceccarini, Maria Rachele, Marinelli, Alessia, Imbriano, Anna, Beccari, Tommaso, Primavilla, Sara, Valiani, Andrea, Ricci, Maurizio, Perioli, Luana
Format: Article
Language:English
Subjects:
Allantoin - chemistry
Animals
Anti-Infective Agents - administration & dosage
Anti-Infective Agents - chemistry
Anti-Infective Agents - pharmacology
Antimicrobial activity
Elasticity
Emulgel
Gels
Helix, Snails
Humans
Hyaluronic Acid - chemistry
Hyaluronic Acid - pharmacology
Keartinocytes
Keratinocytes - drug effects
Microbial Sensitivity Tests
Skin
Skin elasticity
Snail slime
Snails
Stability
Wound Healing - drug effects
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Summary:[Display omitted] Snail slime is an interesting material for effective dermatological use (e.g. wounds). Its properties are stricly connected to the origin. In this paper a snail slime, deriving from the species Helix aspersa Muller and obtained from a company, was deeply characterized and then properly formulated. The slime, obtained by Donatella Veroni method, was firstly submitted to NMR analysis in order to evaluate the chemical composition. The main molecules found are glycolate and allantoin, well known for their activities in wound healing promotion. In vitro experiments performed on keratinocytes, revealed the snail slime ability to promote cellular well-being. Moreover, the microbiological analysis showed high activity against many strains involved in wounds infections such as gram+ (e.g. S. aureus, S. pyogenes), gram- (e.g. P. aeruginosa, E. coli) and the yeast C. albicans. The effect on skin elasticity was evaluated as well by the instrument Cutometer® dualMPA580. The snail slime was then formulated as hydrophilic gel, using a combination of corn starch and sodium hyaluronate as polymers, then used as external water phase of an O/W emulgel. The formulation is physically stable and easily spreadable and demonstrated antimicrobial activity as observed for slime alone, suggesting its suitability to be used for wound treatment.
ISSN:0378-5173
1873-3476
1873-3476
DOI:10.1016/j.ijpharm.2024.124337