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Predicting sepsis at emergency department triage: Implementing clinical and laboratory markers within the first nursing assessment to enhance diagnostic accuracy
Background Early identification of sepsis in the emergency department (ED) triage is both valuable and challenging. Numerous studies have endeavored to pinpoint clinical and biochemical criteria to assist clinicians in the prompt diagnosis of sepsis, but few studies have assessed the efficacy of the...
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| Published in: | Journal of nursing scholarship 2024-11, Vol.56 (6), p.757-766 |
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| container_title | Journal of nursing scholarship |
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| creator | Sisto, Ugo Giulio Di Bella, Stefano Porta, Elisa Franzoi, Giorgia Cominotto, Franco Guzzardi, Elena Artusi, Nicola Giudice, Caterina Anna Dal Bo, Eugenia Collot, Nicholas Sirianni, Francesca Russo, Savino Sanson, Gianfranco |
| description | Background
Early identification of sepsis in the emergency department (ED) triage is both valuable and challenging. Numerous studies have endeavored to pinpoint clinical and biochemical criteria to assist clinicians in the prompt diagnosis of sepsis, but few studies have assessed the efficacy of these criteria in the ED triage setting. The aim of the study was to explore the accuracy of clinical and laboratory markers evaluated at the triage level in identifying patients with sepsis.
Methods
A prospective study was conducted in a large academic urban hospital, implementing a triage protocol aimed at early identification of septic patients based on clinical and laboratory markers. A multidisciplinary panel of experts reviewed cases to ensure accurate identification of septic patients. Variables analyzed included: Charlson comorbidity index, mean arterial pressure (MAP), partial pressure of carbon dioxide (PetCO2), white cell count, eosinophil count, C‐reactive protein to albumin ratio, procalcitonin, and lactate.
Results
A total of 235 patients were included. Multivariable analysis identified procalcitonin ≥1 ng/mL (OR 5.2; p |
| doi_str_mv | 10.1111/jnu.13002 |
| format | article |
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Early identification of sepsis in the emergency department (ED) triage is both valuable and challenging. Numerous studies have endeavored to pinpoint clinical and biochemical criteria to assist clinicians in the prompt diagnosis of sepsis, but few studies have assessed the efficacy of these criteria in the ED triage setting. The aim of the study was to explore the accuracy of clinical and laboratory markers evaluated at the triage level in identifying patients with sepsis.
Methods
A prospective study was conducted in a large academic urban hospital, implementing a triage protocol aimed at early identification of septic patients based on clinical and laboratory markers. A multidisciplinary panel of experts reviewed cases to ensure accurate identification of septic patients. Variables analyzed included: Charlson comorbidity index, mean arterial pressure (MAP), partial pressure of carbon dioxide (PetCO2), white cell count, eosinophil count, C‐reactive protein to albumin ratio, procalcitonin, and lactate.
Results
A total of 235 patients were included. Multivariable analysis identified procalcitonin ≥1 ng/mL (OR 5.2; p < 0.001); CRP‐to‐albumin ratio ≥32 (OR 6.6; p < 0.001); PetCO2 ≤ 28 mmHg (OR 2.7; p = 0.031), and MAP <85 mmHg (OR 7.5; p < 0.001) as independent predictors for sepsis. MAP ≥85 mmHg, CRP/albumin ratio <32, and procalcitonin <1 ng/mL demonstrated negative predictive values for sepsis of 90%, 89%, and 88%, respectively.
Conclusions
Our study underscores the significance of procalcitonin and mean arterial pressure, while introducing CRP/albumin ratio and PetCO2 as important variables to consider in the very initial assessment of patients with suspected sepsis in the ED.
Clinical Relevance
Early identification of sepsis since the emergency department (ED) triage is challenging
Implementing the ED triage protocol with simple clinical and laboratory markers allows to recognize patients with sepsis with a very good discriminatory power (AUC 0.88)]]></description><identifier>ISSN: 1527-6546</identifier><identifier>ISSN: 1547-5069</identifier><identifier>EISSN: 1547-5069</identifier><identifier>DOI: 10.1111/jnu.13002</identifier><identifier>PMID: 38886920</identifier><language>eng</language><publisher>United States</publisher><subject>Adult ; Aged ; Biomarkers - blood ; C-Reactive Protein - analysis ; CRP/albumin ratio ; emergency department triage ; Emergency Service, Hospital - statistics & numerical data ; eosinophil count ; Female ; Humans ; Male ; mean arterial pressure ; Middle Aged ; Nursing Assessment - methods ; PetCO2 ; procalcitonin ; Procalcitonin - blood ; Prospective Studies ; sepsis ; Sepsis - blood ; Sepsis - diagnosis ; Triage - methods</subject><ispartof>Journal of nursing scholarship, 2024-11, Vol.56 (6), p.757-766</ispartof><rights>2024 Sigma Theta Tau International.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c2152-9c69b1c790e0a1fa7d97fed0698b7e409e2d157a64bdd2148e0e3b135daba4b53</cites><orcidid>0000-0001-6121-7009 ; 0000-0001-8319-635X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902,33589,34508</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38886920$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sisto, Ugo Giulio</creatorcontrib><creatorcontrib>Di Bella, Stefano</creatorcontrib><creatorcontrib>Porta, Elisa</creatorcontrib><creatorcontrib>Franzoi, Giorgia</creatorcontrib><creatorcontrib>Cominotto, Franco</creatorcontrib><creatorcontrib>Guzzardi, Elena</creatorcontrib><creatorcontrib>Artusi, Nicola</creatorcontrib><creatorcontrib>Giudice, Caterina Anna</creatorcontrib><creatorcontrib>Dal Bo, Eugenia</creatorcontrib><creatorcontrib>Collot, Nicholas</creatorcontrib><creatorcontrib>Sirianni, Francesca</creatorcontrib><creatorcontrib>Russo, Savino</creatorcontrib><creatorcontrib>Sanson, Gianfranco</creatorcontrib><title>Predicting sepsis at emergency department triage: Implementing clinical and laboratory markers within the first nursing assessment to enhance diagnostic accuracy</title><title>Journal of nursing scholarship</title><addtitle>J Nurs Scholarsh</addtitle><description><![CDATA[Background
Early identification of sepsis in the emergency department (ED) triage is both valuable and challenging. Numerous studies have endeavored to pinpoint clinical and biochemical criteria to assist clinicians in the prompt diagnosis of sepsis, but few studies have assessed the efficacy of these criteria in the ED triage setting. The aim of the study was to explore the accuracy of clinical and laboratory markers evaluated at the triage level in identifying patients with sepsis.
Methods
A prospective study was conducted in a large academic urban hospital, implementing a triage protocol aimed at early identification of septic patients based on clinical and laboratory markers. A multidisciplinary panel of experts reviewed cases to ensure accurate identification of septic patients. Variables analyzed included: Charlson comorbidity index, mean arterial pressure (MAP), partial pressure of carbon dioxide (PetCO2), white cell count, eosinophil count, C‐reactive protein to albumin ratio, procalcitonin, and lactate.
Results
A total of 235 patients were included. Multivariable analysis identified procalcitonin ≥1 ng/mL (OR 5.2; p < 0.001); CRP‐to‐albumin ratio ≥32 (OR 6.6; p < 0.001); PetCO2 ≤ 28 mmHg (OR 2.7; p = 0.031), and MAP <85 mmHg (OR 7.5; p < 0.001) as independent predictors for sepsis. MAP ≥85 mmHg, CRP/albumin ratio <32, and procalcitonin <1 ng/mL demonstrated negative predictive values for sepsis of 90%, 89%, and 88%, respectively.
Conclusions
Our study underscores the significance of procalcitonin and mean arterial pressure, while introducing CRP/albumin ratio and PetCO2 as important variables to consider in the very initial assessment of patients with suspected sepsis in the ED.
Clinical Relevance
Early identification of sepsis since the emergency department (ED) triage is challenging
Implementing the ED triage protocol with simple clinical and laboratory markers allows to recognize patients with sepsis with a very good discriminatory power (AUC 0.88)]]></description><subject>Adult</subject><subject>Aged</subject><subject>Biomarkers - blood</subject><subject>C-Reactive Protein - analysis</subject><subject>CRP/albumin ratio</subject><subject>emergency department triage</subject><subject>Emergency Service, Hospital - statistics & numerical data</subject><subject>eosinophil count</subject><subject>Female</subject><subject>Humans</subject><subject>Male</subject><subject>mean arterial pressure</subject><subject>Middle Aged</subject><subject>Nursing Assessment - methods</subject><subject>PetCO2</subject><subject>procalcitonin</subject><subject>Procalcitonin - blood</subject><subject>Prospective Studies</subject><subject>sepsis</subject><subject>Sepsis - blood</subject><subject>Sepsis - diagnosis</subject><subject>Triage - methods</subject><issn>1527-6546</issn><issn>1547-5069</issn><issn>1547-5069</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><recordid>eNp1kctu1jAQRi0EohdY8ALIS7pIa-fmhF1VlV5UAQu6jib25P9dEif1OKryOLwpTlO6w5uxrDPHmvkY-yTFqYzn7MHNpzITIn3DDmWRq6QQZf12vacqKYu8PGBHRA9CiFKq7D07yKqqKutUHLI_Pz0aq4N1O044kSUOgeOAfodOL9zgBD4M6AIP3sIOv_KbYepxfVl7dG-d1dBzcIb30I4ewugXPoD_jZ74kw1763jYI--sp8Dd7GltBCIk2sQjR7cHp5Gb-IUbKVjNQevZg14-sHcd9IQfX-oxu_92-eviOrn7cXVzcX6X6DTOmdS6rFupVS1QgOxAmVp1aOIiqlZhLmpMjSwUlHlrTCrzCgVmrcwKAy3kbZEdsy-bd_Lj44wUmsGSxr4Hh-NMTSaUUHUuizKiJxuq_UjksWsmb-PESyNFsybSxESa50Qi-_lFO7cDmlfyXwQRONuAJ9vj8n9Tc_v9flP-Bc3OmlY</recordid><startdate>202411</startdate><enddate>202411</enddate><creator>Sisto, Ugo Giulio</creator><creator>Di Bella, Stefano</creator><creator>Porta, Elisa</creator><creator>Franzoi, Giorgia</creator><creator>Cominotto, Franco</creator><creator>Guzzardi, Elena</creator><creator>Artusi, Nicola</creator><creator>Giudice, Caterina Anna</creator><creator>Dal Bo, Eugenia</creator><creator>Collot, Nicholas</creator><creator>Sirianni, Francesca</creator><creator>Russo, Savino</creator><creator>Sanson, Gianfranco</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-6121-7009</orcidid><orcidid>https://orcid.org/0000-0001-8319-635X</orcidid></search><sort><creationdate>202411</creationdate><title>Predicting sepsis at emergency department triage: Implementing clinical and laboratory markers within the first nursing assessment to enhance diagnostic accuracy</title><author>Sisto, Ugo Giulio ; Di Bella, Stefano ; Porta, Elisa ; Franzoi, Giorgia ; Cominotto, Franco ; Guzzardi, Elena ; Artusi, Nicola ; Giudice, Caterina Anna ; Dal Bo, Eugenia ; Collot, Nicholas ; Sirianni, Francesca ; Russo, Savino ; Sanson, Gianfranco</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c2152-9c69b1c790e0a1fa7d97fed0698b7e409e2d157a64bdd2148e0e3b135daba4b53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Biomarkers - blood</topic><topic>C-Reactive Protein - analysis</topic><topic>CRP/albumin ratio</topic><topic>emergency department triage</topic><topic>Emergency Service, Hospital - statistics & numerical data</topic><topic>eosinophil count</topic><topic>Female</topic><topic>Humans</topic><topic>Male</topic><topic>mean arterial pressure</topic><topic>Middle Aged</topic><topic>Nursing Assessment - methods</topic><topic>PetCO2</topic><topic>procalcitonin</topic><topic>Procalcitonin - blood</topic><topic>Prospective Studies</topic><topic>sepsis</topic><topic>Sepsis - blood</topic><topic>Sepsis - diagnosis</topic><topic>Triage - methods</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sisto, Ugo Giulio</creatorcontrib><creatorcontrib>Di Bella, Stefano</creatorcontrib><creatorcontrib>Porta, Elisa</creatorcontrib><creatorcontrib>Franzoi, Giorgia</creatorcontrib><creatorcontrib>Cominotto, Franco</creatorcontrib><creatorcontrib>Guzzardi, Elena</creatorcontrib><creatorcontrib>Artusi, Nicola</creatorcontrib><creatorcontrib>Giudice, Caterina Anna</creatorcontrib><creatorcontrib>Dal Bo, Eugenia</creatorcontrib><creatorcontrib>Collot, Nicholas</creatorcontrib><creatorcontrib>Sirianni, Francesca</creatorcontrib><creatorcontrib>Russo, Savino</creatorcontrib><creatorcontrib>Sanson, Gianfranco</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of nursing scholarship</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sisto, Ugo Giulio</au><au>Di Bella, Stefano</au><au>Porta, Elisa</au><au>Franzoi, Giorgia</au><au>Cominotto, Franco</au><au>Guzzardi, Elena</au><au>Artusi, Nicola</au><au>Giudice, Caterina Anna</au><au>Dal Bo, Eugenia</au><au>Collot, Nicholas</au><au>Sirianni, Francesca</au><au>Russo, Savino</au><au>Sanson, Gianfranco</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Predicting sepsis at emergency department triage: Implementing clinical and laboratory markers within the first nursing assessment to enhance diagnostic accuracy</atitle><jtitle>Journal of nursing scholarship</jtitle><addtitle>J Nurs Scholarsh</addtitle><date>2024-11</date><risdate>2024</risdate><volume>56</volume><issue>6</issue><spage>757</spage><epage>766</epage><pages>757-766</pages><issn>1527-6546</issn><issn>1547-5069</issn><eissn>1547-5069</eissn><abstract><![CDATA[Background
Early identification of sepsis in the emergency department (ED) triage is both valuable and challenging. Numerous studies have endeavored to pinpoint clinical and biochemical criteria to assist clinicians in the prompt diagnosis of sepsis, but few studies have assessed the efficacy of these criteria in the ED triage setting. The aim of the study was to explore the accuracy of clinical and laboratory markers evaluated at the triage level in identifying patients with sepsis.
Methods
A prospective study was conducted in a large academic urban hospital, implementing a triage protocol aimed at early identification of septic patients based on clinical and laboratory markers. A multidisciplinary panel of experts reviewed cases to ensure accurate identification of septic patients. Variables analyzed included: Charlson comorbidity index, mean arterial pressure (MAP), partial pressure of carbon dioxide (PetCO2), white cell count, eosinophil count, C‐reactive protein to albumin ratio, procalcitonin, and lactate.
Results
A total of 235 patients were included. Multivariable analysis identified procalcitonin ≥1 ng/mL (OR 5.2; p < 0.001); CRP‐to‐albumin ratio ≥32 (OR 6.6; p < 0.001); PetCO2 ≤ 28 mmHg (OR 2.7; p = 0.031), and MAP <85 mmHg (OR 7.5; p < 0.001) as independent predictors for sepsis. MAP ≥85 mmHg, CRP/albumin ratio <32, and procalcitonin <1 ng/mL demonstrated negative predictive values for sepsis of 90%, 89%, and 88%, respectively.
Conclusions
Our study underscores the significance of procalcitonin and mean arterial pressure, while introducing CRP/albumin ratio and PetCO2 as important variables to consider in the very initial assessment of patients with suspected sepsis in the ED.
Clinical Relevance
Early identification of sepsis since the emergency department (ED) triage is challenging
Implementing the ED triage protocol with simple clinical and laboratory markers allows to recognize patients with sepsis with a very good discriminatory power (AUC 0.88)]]></abstract><cop>United States</cop><pmid>38886920</pmid><doi>10.1111/jnu.13002</doi><tpages>10</tpages><orcidid>https://orcid.org/0000-0001-6121-7009</orcidid><orcidid>https://orcid.org/0000-0001-8319-635X</orcidid></addata></record> |
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| subjects | Adult Aged Biomarkers - blood C-Reactive Protein - analysis CRP/albumin ratio emergency department triage Emergency Service, Hospital - statistics & numerical data eosinophil count Female Humans Male mean arterial pressure Middle Aged Nursing Assessment - methods PetCO2 procalcitonin Procalcitonin - blood Prospective Studies sepsis Sepsis - blood Sepsis - diagnosis Triage - methods |
| title | Predicting sepsis at emergency department triage: Implementing clinical and laboratory markers within the first nursing assessment to enhance diagnostic accuracy |
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