Longitudinal study of the role of salivary proteins on radiation-related caries onset in head and neck cancer patients using 5000 ppm fluoride dentifrice up to one-year post-intensity modulated radiotherapy

• Published in: Clinical oral investigations 2024-06, Vol.28 (7), p.379, Article 379
• Main Authors: Agurto, Maria Gonzalez, Bozorgi, Sophie S, Carpenter, Guy, Ramirez, Valeria, Burke, Mary, Felipe Gutierrez, Mario, Cordova, Christian, Banerjee, Avijit
• Format: Article
• Language: English
• Subjects: Adult; Aged; Cystatins; Dental caries; Dental Caries - etiology; Dental Caries - prevention & control; Dentifrices - therapeutic use; Dentistry; Diagnosis; DMF Index; Female; Fluorides; Fluorides - therapeutic use; Head & neck cancer; Head and neck; Head and Neck Neoplasms - radiotherapy; Humans; Immunoglobulin A; Immunoglobulin A - analysis; Immunoglobulins; Longitudinal Studies; Male; Medicine; Middle Aged; Precision medicine; Proteins; Quality of life; Radiation therapy; Radiotherapy, Intensity-Modulated; Saliva - metabolism; Salivary Proteins and Peptides; α-Amylase
• ISSN: 1436-3771; 1432-6981; 1436-3771
• DOI: 10.1007/s00784-024-05788-y

Objectives Longitudinal assessment of the role of specific proteins on radiotherapy caries (RC) onset in head and neck cancer patients(HNC) up to one-year post-IMRT using a 5000ppm fluoride paste daily. Materials and methods Dental status/salivary protein data were obtained from 40 HNC patients pre-IMRT, six months (T1) and 12 months (T2) post-IMRT (ethical approval/consent). DMFT/salivary parameters were quantified, including flow rate, mucin 5B/7, Immunoglobulin A (IgA), cystatin S and α-amylase. Results 45% patients had at least one carious lesion at T2, a significant reduction in the number of remaining teeth (65%