Prognostic relationship between high sensitivity troponin I level, hematoma volume and glasgow coma score in patients diagnosed with spontaneous intracerebral hemorrhage

Background Intracranial hemorrhages is one of the major causes of mortality and morbidity worldwide, and there is still no effective biomarker to predict prognosis. Aim We aimed to determine the effectiveness of high sensitive troponin I (hs-cTn-I) levels to predict the prognosis of spontaneous intr...

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Bibliographic Details
Published in:Irish journal of medical science 2024-10, Vol.193 (5), p.2559-2565
Main Authors: Ulger, Huseyin, Icme, Ferhat, Parlatan, Cenk, Avci, Begum Seyda, Aksay, Erdem, Avci, Akkan
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Biomarkers - blood
Cerebral Hemorrhage - blood
Cerebral Hemorrhage - diagnostic imaging
Cerebral Hemorrhage - mortality
Family Medicine
Female
General Practice
Glasgow Coma Scale
Hematoma - blood
Hematoma - diagnostic imaging
Humans
Internal Medicine
Male
Medicine
Medicine & Public Health
Middle Aged
Original Article
Prognosis
Retrospective Studies
Tomography, X-Ray Computed
Troponin I - blood
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Summary:Background Intracranial hemorrhages is one of the major causes of mortality and morbidity worldwide, and there is still no effective biomarker to predict prognosis. Aim We aimed to determine the effectiveness of high sensitive troponin I (hs-cTn-I) levels to predict the prognosis of spontaneous intracerebral hemorrhage (sICH) by comparing Glasgow Coma Score (GCS) and hematoma volume with hs-cTn-I levels. Methods This study was planned as a retrospective observational study. Patients with available data, over 18 years old and sICH were included in the study. Cerebral computed tomography images were evaluated by a senior radiologist. Hematoma volume was calculated using the ABC/2 formula. Results The study comprised 206 individuals in total 78 (37.86%) women and 128 (62.13%) men. Forty-four (21.35%) of patients died. The sensitivity of GCS, hs-cTn-I, and hematoma volume values were 86.36%, 66.67%, and 59.46%, respectively, with corresponding specificities of 78.75%, 93.02%, and 87.58%. Patients with hs-cTn-I values over 26, GCS values of ≤ 9, and hematoma volume values above 44.16 were found to have higher risk of mortality ( p  = 0.011; p  
ISSN:0021-1265
1863-4362
1863-4362
DOI:10.1007/s11845-024-03737-y