Association of vascular endothelial growth factor‐C, plasma angiotensinogen and left ventricular hypertrophy in patients with hemodialysis

Introduction This study aims to examine the relationship between fluid overload, Vascular Endothelial Growth Factor C (VEGF‐C), plasma Angiotensinogen (pAGT), and echocardiography findings in hemodialysis patients. Methods This was a single‐center, cross‐sectional study. Patients were divided into t...

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Published in:Therapeutic apheresis and dialysis 2024-12, Vol.28 (6), p.904-911
Main Authors: Yeter, Haci Hasan, Levent, Mustafa, Sahiner, Levent, Yildirim, Tolga, Yilmaz, Rahmi
Format: Article
Language:English
Subjects:
Aged
angiotensinogen
Angiotensinogen - blood
Biomarkers - blood
Cross-Sectional Studies
Echocardiography
Female
hemodialysis
Humans
Hypertrophy, Left Ventricular - blood
Hypertrophy, Left Ventricular - etiology
Kidney Failure, Chronic - blood
Kidney Failure, Chronic - complications
Kidney Failure, Chronic - therapy
left ventricular hypertrophy
Male
Middle Aged
Renal Dialysis - methods
Renin-Angiotensin System
vascular endothelial growth factor C
Vascular Endothelial Growth Factor C - blood
Weight Gain
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Summary:Introduction This study aims to examine the relationship between fluid overload, Vascular Endothelial Growth Factor C (VEGF‐C), plasma Angiotensinogen (pAGT), and echocardiography findings in hemodialysis patients. Methods This was a single‐center, cross‐sectional study. Patients were divided into two groups according to mid‐week inter‐dialytic weight gain (mIDWG): (1) mIDWG ≤3% and (2) mIDW >3%. Results A total of 55 patients were enrolled in this study. While the mean pAGT and left ventricular mass index were significantly higher in patients with mIDWG >3% compared to patients with mIDWG ≤3%, VEGF‐C was similar between groups. pAGT ≥76.8 mcg/L, VEGF‐C ≤175.5 pg/ML, and pAGT /VEGF‐C ≥0.45 were significant cut‐offs for the prediction of left ventricular hypertrophy(LVH). Univariate logistic regression analysis revealed that these cut‐off values were significantly associated with LVH. Conclusion Renin‐angiotensin‐aldosterone system activation may persist in hemodialysis patients with excessive IDWG. Additionally, pAGT and VEGF‐C could be risk factors for the development of LVH.
ISSN:1744-9979
1744-9987
1744-9987
DOI:10.1111/1744-9987.14178