Progression of diabetic retinopathy in women with pregestational diabetes during pregnancy and postpartum

Background Diabetic retinopathy (DR) may worsen during pregnancy, but its course in the postpartum remains poorly understood. Understanding the natural history of DR during and after pregnancy can help determine when sight‐threatening DR treatment should be administered. Methods A prospective longit...

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Bibliographic Details
Published in:Clinical & experimental ophthalmology 2024-09, Vol.52 (7), p.761-773
Main Authors: Widyaputri, Felicia, Khong, Edmund W. C., Rogers, Sophie L., Nankervis, Alison J., Conn, Jennifer J., Sasongko, Muhammad B., Shub, Alexis, Fagan, Xavier J., Guest, Daryl, Symons, Robert C. A., Lim, Lyndell L.
Format: Article
Language:English
Subjects:
Adult
Blood pressure
Diabetes
Diabetes mellitus (insulin dependent)
Diabetes mellitus (non-insulin dependent)
Diabetes Mellitus, Type 1 - complications
Diabetes Mellitus, Type 1 - physiopathology
Diabetes Mellitus, Type 2 - complications
Diabetes Mellitus, Type 2 - physiopathology
Diabetic retinopathy
Diabetic Retinopathy - diagnosis
Diabetic Retinopathy - physiopathology
Disease Progression
Eye
Female
Follow-Up Studies
Glycated Hemoglobin - metabolism
Humans
Middle Aged
Postpartum
Postpartum Period
pregestational diabetes
Pregnancy
Pregnancy in Diabetics - diagnosis
Pregnancy in Diabetics - physiopathology
progression
Prospective Studies
Retinopathy
Risk Factors
Tomography, Optical Coherence - methods
Visual Acuity - physiology
Young Adult
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Summary:Background Diabetic retinopathy (DR) may worsen during pregnancy, but its course in the postpartum remains poorly understood. Understanding the natural history of DR during and after pregnancy can help determine when sight‐threatening DR treatment should be administered. Methods A prospective longitudinal cohort study recruited pregnant women with pre‐existing type 1 (T1D) or type 2 diabetes from two tertiary Diabetes Antenatal Clinics in Melbourne, Australia. Eye examination results in early pregnancy, late pregnancy, and up to 12‐months postpartum were compared to determine DR changes. Two‐field fundus photographs and optical coherence tomography scans were used to assess DR severity. Results Overall, 105 (61.4%) women had at least two eye examinations during the observation period. Mean age was 33.5 years (range 19–51); 54 women (51.4%) had T1D; 63% had HbA1c
ISSN:1442-6404
1442-9071
1442-9071
DOI:10.1111/ceo.14410