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Incidence of brain metastasis according to patient race and primary cancer origin: a systematic review
Purpose A systematic review was conducted to investigate differences in incidence and primary origin of synchronous brain metastasis (sBM) in varying racial groups with different primary cancers. Methods Adhering to PRISMA 2020 guidelines a search was conducted using PubMed and Ovid databases for pu...
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| Published in: | Journal of neuro-oncology 2024-09, Vol.169 (3), p.457-467 |
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| Main Authors: | , , , , , , , , , , , , , , |
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| container_end_page | 467 |
| container_issue | 3 |
| container_start_page | 457 |
| container_title | Journal of neuro-oncology |
| container_volume | 169 |
| creator | Gomez, David Feng, Jeffrey J. Cheok, Stephanie Shah, Ishan Dicharry, Holly Cote, David J. Briggs, Robert G. Guerra, Gage A. Peterson, Racheal Salhia, Bodour Neman, Josh Attenello, Frank Chow, Frances Musabelliu, Erion K. Zada, Gabriel |
| description | Purpose
A systematic review was conducted to investigate differences in incidence and primary origin of synchronous brain metastasis (sBM) in varying racial groups with different primary cancers.
Methods
Adhering to PRISMA 2020 guidelines a search was conducted using PubMed and Ovid databases for publications from January 2000 to January 2023, with search terms including combinations of “brain metastasis,” “race,” “ethnicity,” and “incidence.” Three independent reviewers screened for inclusion criteria encompassing studies clearly reporting primary cancer sites, patient demographics including race, and synchronous BM (sBM) incidence.
Results
Of 806 articles, 10 studies comprised of mainly adult patients from the United States met final inclusion for data analysis. Higher sBM incidence proportions were observed in American Indian/Alaska native patients for primary breast (
p
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| doi_str_mv | 10.1007/s11060-024-04748-6 |
| format | article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_3070803757</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>3095822149</sourcerecordid><originalsourceid>FETCH-LOGICAL-c300t-f98724d4159f69de4c23407ab1d1998de2d0970dee3f4edf0ac3611e0bddcb653</originalsourceid><addsrcrecordid>eNp9kUFrGzEQhUVpqR2nf6CHIugll01HK620yq2EJjEYekkgN6GVZo2MV-tI65b8-yqxm0AOgQEd5ntP0nuEfGVwzgDUj8wYSKigFhUIJdpKfiBz1iheKa74RzIHJlXVaHE_Iyc5bwAKxtlnMuNtqyVv5Jz0y-iCx-iQjj3tkg2RDjjZXCZkap0bkw9xTaeR7uwUME402ULb6OkuhcGmR-ps0Sc6prAO8YJamh_zhEPBHU34J-DfU_Kpt9uMX47ngtxd_bq9vKlWv6-Xlz9XleMAU9XrVtXCC9boXmqPwtVcgLId80zr1mPtQSvwiLwX6HuwjkvGEDrvXScbviBnB99dGh_2mCczhOxwu7URx302HBS0wFUJaUG-v0E34z7F8rpC6aatayZ0oeoD5dKYc8LeHD9tGJinFsyhBVNaMM8tGFlE347W-25A_yL5H3sB-AHIZRXXmF7vfsf2H2CDkys</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>3095822149</pqid></control><display><type>article</type><title>Incidence of brain metastasis according to patient race and primary cancer origin: a systematic review</title><source>Springer Nature</source><creator>Gomez, David ; Feng, Jeffrey J. ; Cheok, Stephanie ; Shah, Ishan ; Dicharry, Holly ; Cote, David J. ; Briggs, Robert G. ; Guerra, Gage A. ; Peterson, Racheal ; Salhia, Bodour ; Neman, Josh ; Attenello, Frank ; Chow, Frances ; Musabelliu, Erion K. ; Zada, Gabriel</creator><creatorcontrib>Gomez, David ; Feng, Jeffrey J. ; Cheok, Stephanie ; Shah, Ishan ; Dicharry, Holly ; Cote, David J. ; Briggs, Robert G. ; Guerra, Gage A. ; Peterson, Racheal ; Salhia, Bodour ; Neman, Josh ; Attenello, Frank ; Chow, Frances ; Musabelliu, Erion K. ; Zada, Gabriel</creatorcontrib><description>Purpose
A systematic review was conducted to investigate differences in incidence and primary origin of synchronous brain metastasis (sBM) in varying racial groups with different primary cancers.
Methods
Adhering to PRISMA 2020 guidelines a search was conducted using PubMed and Ovid databases for publications from January 2000 to January 2023, with search terms including combinations of “brain metastasis,” “race,” “ethnicity,” and “incidence.” Three independent reviewers screened for inclusion criteria encompassing studies clearly reporting primary cancer sites, patient demographics including race, and synchronous BM (sBM) incidence.
Results
Of 806 articles, 10 studies comprised of mainly adult patients from the United States met final inclusion for data analysis. Higher sBM incidence proportions were observed in American Indian/Alaska native patients for primary breast (
p
< 0.001), colorectal (
p
= 0.015), and esophageal cancers (
p
= 0.024) as well as in Asian or Pacific islanders for primary stomach (
p
< 0.001), thyroid (
p
= 0.006), and lung/bronchus cancers (
p
< 0.001) yet higher proportions in White patients for malignant melanoma (
p
< 0.001). Compared to White patients, Black patients had higher sBM incidence likelihood in breast cancer (OR = 1.27,
p
= 0.01) but lower likelihood in renal (OR = 0.46,
p
< 0.001) and esophageal cancers (OR = 0.31,
p
= 0.005). American Indian/Alaska native patients had a higher sBM likelihood (OR = 3.78,
p
= 0.004) relative to White patients in esophageal cancer.
Conclusions
These findings reveal several comparative racial differences in sBM incidence arising from different primary cancer origins, underscoring a need for further research to explain these variations. Identifying the factors contributing to these disparities holds the potential to promote greater equity in oncological care according to cancer type.</description><identifier>ISSN: 0167-594X</identifier><identifier>ISSN: 1573-7373</identifier><identifier>EISSN: 1573-7373</identifier><identifier>DOI: 10.1007/s11060-024-04748-6</identifier><identifier>PMID: 38896356</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Brain Neoplasms - epidemiology ; Brain Neoplasms - secondary ; Bronchus ; Cancer ; Esophagus ; Humans ; Incidence ; Medicine ; Medicine & Public Health ; Melanoma ; Metastases ; Metastasis ; Neoplasms - epidemiology ; Neoplasms - pathology ; Neurology ; Oncology ; Patients ; Race ; Racial Groups - statistics & numerical data ; Review ; Systematic review</subject><ispartof>Journal of neuro-oncology, 2024-09, Vol.169 (3), p.457-467</ispartof><rights>The Author(s) 2024</rights><rights>2024. The Author(s).</rights><rights>The Author(s) 2024. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c300t-f98724d4159f69de4c23407ab1d1998de2d0970dee3f4edf0ac3611e0bddcb653</cites><orcidid>0000-0003-3612-661X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27903,27904</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38896356$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Gomez, David</creatorcontrib><creatorcontrib>Feng, Jeffrey J.</creatorcontrib><creatorcontrib>Cheok, Stephanie</creatorcontrib><creatorcontrib>Shah, Ishan</creatorcontrib><creatorcontrib>Dicharry, Holly</creatorcontrib><creatorcontrib>Cote, David J.</creatorcontrib><creatorcontrib>Briggs, Robert G.</creatorcontrib><creatorcontrib>Guerra, Gage A.</creatorcontrib><creatorcontrib>Peterson, Racheal</creatorcontrib><creatorcontrib>Salhia, Bodour</creatorcontrib><creatorcontrib>Neman, Josh</creatorcontrib><creatorcontrib>Attenello, Frank</creatorcontrib><creatorcontrib>Chow, Frances</creatorcontrib><creatorcontrib>Musabelliu, Erion K.</creatorcontrib><creatorcontrib>Zada, Gabriel</creatorcontrib><title>Incidence of brain metastasis according to patient race and primary cancer origin: a systematic review</title><title>Journal of neuro-oncology</title><addtitle>J Neurooncol</addtitle><addtitle>J Neurooncol</addtitle><description>Purpose
A systematic review was conducted to investigate differences in incidence and primary origin of synchronous brain metastasis (sBM) in varying racial groups with different primary cancers.
Methods
Adhering to PRISMA 2020 guidelines a search was conducted using PubMed and Ovid databases for publications from January 2000 to January 2023, with search terms including combinations of “brain metastasis,” “race,” “ethnicity,” and “incidence.” Three independent reviewers screened for inclusion criteria encompassing studies clearly reporting primary cancer sites, patient demographics including race, and synchronous BM (sBM) incidence.
Results
Of 806 articles, 10 studies comprised of mainly adult patients from the United States met final inclusion for data analysis. Higher sBM incidence proportions were observed in American Indian/Alaska native patients for primary breast (
p
< 0.001), colorectal (
p
= 0.015), and esophageal cancers (
p
= 0.024) as well as in Asian or Pacific islanders for primary stomach (
p
< 0.001), thyroid (
p
= 0.006), and lung/bronchus cancers (
p
< 0.001) yet higher proportions in White patients for malignant melanoma (
p
< 0.001). Compared to White patients, Black patients had higher sBM incidence likelihood in breast cancer (OR = 1.27,
p
= 0.01) but lower likelihood in renal (OR = 0.46,
p
< 0.001) and esophageal cancers (OR = 0.31,
p
= 0.005). American Indian/Alaska native patients had a higher sBM likelihood (OR = 3.78,
p
= 0.004) relative to White patients in esophageal cancer.
Conclusions
These findings reveal several comparative racial differences in sBM incidence arising from different primary cancer origins, underscoring a need for further research to explain these variations. Identifying the factors contributing to these disparities holds the potential to promote greater equity in oncological care according to cancer type.</description><subject>Brain Neoplasms - epidemiology</subject><subject>Brain Neoplasms - secondary</subject><subject>Bronchus</subject><subject>Cancer</subject><subject>Esophagus</subject><subject>Humans</subject><subject>Incidence</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Melanoma</subject><subject>Metastases</subject><subject>Metastasis</subject><subject>Neoplasms - epidemiology</subject><subject>Neoplasms - pathology</subject><subject>Neurology</subject><subject>Oncology</subject><subject>Patients</subject><subject>Race</subject><subject>Racial Groups - statistics & numerical data</subject><subject>Review</subject><subject>Systematic review</subject><issn>0167-594X</issn><issn>1573-7373</issn><issn>1573-7373</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><recordid>eNp9kUFrGzEQhUVpqR2nf6CHIugll01HK620yq2EJjEYekkgN6GVZo2MV-tI65b8-yqxm0AOgQEd5ntP0nuEfGVwzgDUj8wYSKigFhUIJdpKfiBz1iheKa74RzIHJlXVaHE_Iyc5bwAKxtlnMuNtqyVv5Jz0y-iCx-iQjj3tkg2RDjjZXCZkap0bkw9xTaeR7uwUME402ULb6OkuhcGmR-ps0Sc6prAO8YJamh_zhEPBHU34J-DfU_Kpt9uMX47ngtxd_bq9vKlWv6-Xlz9XleMAU9XrVtXCC9boXmqPwtVcgLId80zr1mPtQSvwiLwX6HuwjkvGEDrvXScbviBnB99dGh_2mCczhOxwu7URx302HBS0wFUJaUG-v0E34z7F8rpC6aatayZ0oeoD5dKYc8LeHD9tGJinFsyhBVNaMM8tGFlE347W-25A_yL5H3sB-AHIZRXXmF7vfsf2H2CDkys</recordid><startdate>20240901</startdate><enddate>20240901</enddate><creator>Gomez, David</creator><creator>Feng, Jeffrey J.</creator><creator>Cheok, Stephanie</creator><creator>Shah, Ishan</creator><creator>Dicharry, Holly</creator><creator>Cote, David J.</creator><creator>Briggs, Robert G.</creator><creator>Guerra, Gage A.</creator><creator>Peterson, Racheal</creator><creator>Salhia, Bodour</creator><creator>Neman, Josh</creator><creator>Attenello, Frank</creator><creator>Chow, Frances</creator><creator>Musabelliu, Erion K.</creator><creator>Zada, Gabriel</creator><general>Springer US</general><general>Springer Nature B.V</general><scope>C6C</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>K9.</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-3612-661X</orcidid></search><sort><creationdate>20240901</creationdate><title>Incidence of brain metastasis according to patient race and primary cancer origin: a systematic review</title><author>Gomez, David ; Feng, Jeffrey J. ; Cheok, Stephanie ; Shah, Ishan ; Dicharry, Holly ; Cote, David J. ; Briggs, Robert G. ; Guerra, Gage A. ; Peterson, Racheal ; Salhia, Bodour ; Neman, Josh ; Attenello, Frank ; Chow, Frances ; Musabelliu, Erion K. ; Zada, Gabriel</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c300t-f98724d4159f69de4c23407ab1d1998de2d0970dee3f4edf0ac3611e0bddcb653</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Brain Neoplasms - epidemiology</topic><topic>Brain Neoplasms - secondary</topic><topic>Bronchus</topic><topic>Cancer</topic><topic>Esophagus</topic><topic>Humans</topic><topic>Incidence</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Melanoma</topic><topic>Metastases</topic><topic>Metastasis</topic><topic>Neoplasms - epidemiology</topic><topic>Neoplasms - pathology</topic><topic>Neurology</topic><topic>Oncology</topic><topic>Patients</topic><topic>Race</topic><topic>Racial Groups - statistics & numerical data</topic><topic>Review</topic><topic>Systematic review</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Gomez, David</creatorcontrib><creatorcontrib>Feng, Jeffrey J.</creatorcontrib><creatorcontrib>Cheok, Stephanie</creatorcontrib><creatorcontrib>Shah, Ishan</creatorcontrib><creatorcontrib>Dicharry, Holly</creatorcontrib><creatorcontrib>Cote, David J.</creatorcontrib><creatorcontrib>Briggs, Robert G.</creatorcontrib><creatorcontrib>Guerra, Gage A.</creatorcontrib><creatorcontrib>Peterson, Racheal</creatorcontrib><creatorcontrib>Salhia, Bodour</creatorcontrib><creatorcontrib>Neman, Josh</creatorcontrib><creatorcontrib>Attenello, Frank</creatorcontrib><creatorcontrib>Chow, Frances</creatorcontrib><creatorcontrib>Musabelliu, Erion K.</creatorcontrib><creatorcontrib>Zada, Gabriel</creatorcontrib><collection>SpringerOpen</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of neuro-oncology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Gomez, David</au><au>Feng, Jeffrey J.</au><au>Cheok, Stephanie</au><au>Shah, Ishan</au><au>Dicharry, Holly</au><au>Cote, David J.</au><au>Briggs, Robert G.</au><au>Guerra, Gage A.</au><au>Peterson, Racheal</au><au>Salhia, Bodour</au><au>Neman, Josh</au><au>Attenello, Frank</au><au>Chow, Frances</au><au>Musabelliu, Erion K.</au><au>Zada, Gabriel</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Incidence of brain metastasis according to patient race and primary cancer origin: a systematic review</atitle><jtitle>Journal of neuro-oncology</jtitle><stitle>J Neurooncol</stitle><addtitle>J Neurooncol</addtitle><date>2024-09-01</date><risdate>2024</risdate><volume>169</volume><issue>3</issue><spage>457</spage><epage>467</epage><pages>457-467</pages><issn>0167-594X</issn><issn>1573-7373</issn><eissn>1573-7373</eissn><abstract>Purpose
A systematic review was conducted to investigate differences in incidence and primary origin of synchronous brain metastasis (sBM) in varying racial groups with different primary cancers.
Methods
Adhering to PRISMA 2020 guidelines a search was conducted using PubMed and Ovid databases for publications from January 2000 to January 2023, with search terms including combinations of “brain metastasis,” “race,” “ethnicity,” and “incidence.” Three independent reviewers screened for inclusion criteria encompassing studies clearly reporting primary cancer sites, patient demographics including race, and synchronous BM (sBM) incidence.
Results
Of 806 articles, 10 studies comprised of mainly adult patients from the United States met final inclusion for data analysis. Higher sBM incidence proportions were observed in American Indian/Alaska native patients for primary breast (
p
< 0.001), colorectal (
p
= 0.015), and esophageal cancers (
p
= 0.024) as well as in Asian or Pacific islanders for primary stomach (
p
< 0.001), thyroid (
p
= 0.006), and lung/bronchus cancers (
p
< 0.001) yet higher proportions in White patients for malignant melanoma (
p
< 0.001). Compared to White patients, Black patients had higher sBM incidence likelihood in breast cancer (OR = 1.27,
p
= 0.01) but lower likelihood in renal (OR = 0.46,
p
< 0.001) and esophageal cancers (OR = 0.31,
p
= 0.005). American Indian/Alaska native patients had a higher sBM likelihood (OR = 3.78,
p
= 0.004) relative to White patients in esophageal cancer.
Conclusions
These findings reveal several comparative racial differences in sBM incidence arising from different primary cancer origins, underscoring a need for further research to explain these variations. Identifying the factors contributing to these disparities holds the potential to promote greater equity in oncological care according to cancer type.</abstract><cop>New York</cop><pub>Springer US</pub><pmid>38896356</pmid><doi>10.1007/s11060-024-04748-6</doi><tpages>11</tpages><orcidid>https://orcid.org/0000-0003-3612-661X</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0167-594X |
| ispartof | Journal of neuro-oncology, 2024-09, Vol.169 (3), p.457-467 |
| issn | 0167-594X 1573-7373 1573-7373 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_3070803757 |
| source | Springer Nature |
| subjects | Brain Neoplasms - epidemiology Brain Neoplasms - secondary Bronchus Cancer Esophagus Humans Incidence Medicine Medicine & Public Health Melanoma Metastases Metastasis Neoplasms - epidemiology Neoplasms - pathology Neurology Oncology Patients Race Racial Groups - statistics & numerical data Review Systematic review |
| title | Incidence of brain metastasis according to patient race and primary cancer origin: a systematic review |
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