Thyrotropin (TSH) and thyroid autoimmunity are predictive factors for the incidental discovery of papillary thyroid microcarcinoma during thyroidectomy

Purpose To identify clinical, biological and pathological risk factors for the incidental discovery of papillary thyroid microcarcinomas (PTMCs) in patients undergoing thyroidectomy for presumed benign conditions. Methods Cross sectional, single center study, involving all consecutive patients (N = ...

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Bibliographic Details
Published in:Endocrine 2024-11, Vol.86 (2), p.723-731
Main Authors: Kyrilli, Aglaia, Schoinochoriti, Rafaella, Chatzopoulos, Valerie, Bahar, Nabila, Bouziotis, Jason, D’Haene, Nicky, Salmon, Isabelle, Ruiz, Maria, Corvilain, Bernard
Format: Article
Language:English
Subjects:
Adult
Aged
Autoimmunity
Carcinoma, Papillary - blood
Carcinoma, Papillary - surgery
Cross-Sectional Studies
Diabetes
Endocrinology
Female
Humanities and Social Sciences
Humans
Incidental Findings
Internal Medicine
Male
Medicine
Medicine & Public Health
Middle Aged
multidisciplinary
Original Article
Retrospective Studies
Risk Factors
Science
Thyroid Gland - immunology
Thyroid Gland - pathology
Thyroid Gland - surgery
Thyroid Neoplasms - blood
Thyroid Neoplasms - pathology
Thyroid Neoplasms - surgery
Thyroidectomy
Thyrotropin - blood
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Summary:Purpose To identify clinical, biological and pathological risk factors for the incidental discovery of papillary thyroid microcarcinomas (PTMCs) in patients undergoing thyroidectomy for presumed benign conditions. Methods Cross sectional, single center study, involving all consecutive patients (N = 3015) who were submitted to thyroid surgery between 2001–2019. All medical files were retrospectively reviewed. A total of 1961 patients in the benign group and 145 patients in PTMC group were analyzed. Results No significant differences in age, sex, body mass index, smoking status, thyroid volume or weight and preoperative thyroxine treatment between benign and PTMC groups were observed. Circulating anti- thyroid antibodies, histological thyroiditis and serum thyrotropin (TSH) were significantly associated with PTMC in univariable analysis. Independent risk factors for incidental PTMC by multivariable analysis where possible (OR: 1.51, 95% CI: 0.99–2.28) and certain (OR: 1.74, 95% CI: 1.09–2.78) thyroid autoimmunity ( p  = 0.002) and higher serum TSH (OR: 1.25, 95% CI: 1.08–1.45, p  = 0.03), whereas thyroid lobectomy was associated with a lower risk of PTMC (OR: 0.40, 95% CI: 0.24–0.67, p  
ISSN:1559-0100
1559-0100
DOI:10.1007/s12020-024-03907-z