Clinical significance of serum lactate dehydrogenase combined with a multivariate model for predicting the near-term outcome of primary nasopharyngeal carcinoma

• Published in: Life sciences (1973) 2024-08, Vol.351, p.122856, Article 122856
• Main Authors: Liu, Yuyi, Pan, Zhiyong, Wang, Xinyu, Tian, Yuxiao, Zhu, Song, Wang, Xin
• Format: Article
• Language: English
• Subjects: alkaline phosphatase; blood serum; C-reactive protein; carcinoma; cost effectiveness; data collection; drug therapy; hospitals; Human gammaherpesvirus 4; Lactate dehydrogenase; multivariate analysis; Nasopharyngeal carcinoma; patients; prognosis; Prognostic model; radiotherapy; Recent efficacy; retrospective studies
• ISSN: 0024-3205; 1879-0631; 1879-0631
• DOI: 10.1016/j.lfs.2024.122856

This investigation explores the clinical significance of integrating serum lactate dehydrogenase (LDH) with a multivariate model for assessing the short-term prognosis of primary nasopharyngeal carcinoma (NPC). Epstein-Barr virus (EBV) quantification is a crucial prognostic indicator in NPC cases, but not all patients with NPC test positive for EBV. Furthermore, widespread adoption of EBV-DNA quantification remains challenging due to its high cost. Consequently, it is imperative to incorporate additional convenient and cost-effective prognostic markers to comprehensively evaluate patient outcomes. This retrospective analysis included 203 newly diagnosed NPC cases treated at the Affiliated Qingyuan Hospital of Guangzhou Medical University between January 2018 and March 2022. The dataset included personal information and clinical data, and the treatment protocols followed the CSCO guidelines. Efficacy assessments were based on the RECIST 1.1 criteria and were conducted after induction chemotherapy and one week and three months after radiotherapy. A noteworthy correlation emerged between baseline serum LDH levels and treatment efficacy at one week after radiotherapy (P = 0.03) and at three months after radiotherapy (P