Regulation of Autophagy Signaling Pathways by Ginseng Saponins: A Review

Ginseng saponins (ginsenosides), bioactive compounds derived from ginseng, are widely used natural products with potent therapeutic properties in the management of various ailments, particularly tumors, cardiovascular and cerebrovascular diseases, and immune system disorders. Autophagy, a highly reg...

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Bibliographic Details
Published in:Chemistry & biodiversity 2024-08, Vol.21 (8), p.e202400934-n/a
Main Authors: Zhuang, Zhu‐Jun, Li, Fa‐Jing, Lv, Di, Duan, Heng‐Qian, Chen, Lin‐Yi, Chen, Peng, Shen, Zhi‐Qiang, He, Bo
Format: Article
Language:English
Subjects:
Animals
Autophagy
Autophagy - drug effects
Bioactive compounds
Cerebrovascular diseases
Cerebrovascular system
Ginseng
Ginsenoside
Ginsenosides
Ginsenosides - chemistry
Ginsenosides - pharmacology
Humans
Immune system
Medical treatment
mTOR-dependent signaling pathways
mTOR-independent signaling pathways
Natural products
Organelles
Panax - chemistry
Panax - metabolism
Pharmacology
Saponins
Saponins - chemistry
Saponins - pharmacology
Signal transduction
Signal Transduction - drug effects
Vascular diseases
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Summary:Ginseng saponins (ginsenosides), bioactive compounds derived from ginseng, are widely used natural products with potent therapeutic properties in the management of various ailments, particularly tumors, cardiovascular and cerebrovascular diseases, and immune system disorders. Autophagy, a highly regulated and multistep process involving the breakdown of impaired organelles and macromolecules by autophagolysosomes and autophagy‐related genes (ATGs), has gained increasing attention as a potential target for ginsenoside‐mediated disease treatment. This review aims to provide a comprehensive overview of recent research advances in the understanding of autophagy‐related signaling pathways and the role of ginsenoside‐mediated autophagy regulation. By delving into the intricate autophagy signaling pathways underpinning the pharmacological properties of ginsenosides, we highlight their therapeutic potential in addressing various conditions. Our findings serve as a comprehensive reference for further investigation into the medicinal properties of ginseng or ginseng‐related products.
ISSN:1612-1872
1612-1880
1612-1880
DOI:10.1002/cbdv.202400934