Utility of dual-energy CT and advanced multiparametric MRI based imaging biomarkers of pancreatic fibrosis in grading the severity of chronic pancreatitis

• Published in: Abdominal imaging 2024-10, Vol.49 (10), p.3528-3539
• Main Authors: Narang, Mohak, Singh, Anup, Mahapatra, Soumya Jagannath, Gunjan, Deepak, Sharma, Sanjay, Srivastava, Deep Narayan, Yadav, Rajni, Dash, Nihar Ranjan, Bansal, Virinder Kumar, Pandey, Ravindra Mohan, Garg, Pramod Kumar, Madhusudhan, Kumble Seetharama
• Format: Article
• Language: English
• Subjects: Adult; Biomarkers; Computed tomography; Female; Fibrosis; Fibrosis - diagnostic imaging; Gastroenterology; Hepatology; Humans; Imaging; Iodine; Magnetic resonance imaging; Male; Medical imaging; Medicine; Medicine & Public Health; Middle Aged; Multiparametric Magnetic Resonance Imaging - methods; Pancreas; Pancreas - diagnostic imaging; Pancreas - pathology; Pancreatitis; Pancreatitis, Chronic - diagnostic imaging; Radiology; Relaxation time; Severity of Illness Index; Tomography, X-Ray Computed - methods
• ISSN: 2366-0058; 2366-004X; 2366-0058
• DOI: 10.1007/s00261-024-04443-0

Purpose To non-invasively quantify pancreatic fibrosis and grade severity of chronic pancreatitis (CP) on dual-energy CT (DECT) and multiparametric MRI (mpMRI). Methods We included 72 patients (mean age:30years; 59 men) with suspected or confirmed CP from December 2019 to December 2021 graded as equivocal( n  = 20), mild( n  = 18), and moderate-marked( n  = 34) using composite imaging and endoscopic ultrasound criteria. Study patients underwent multiphasic DECT and mpMRI of the abdomen. Normalized iodine concentration(NIC) and fat fraction(FF) on 6-minute delayed DECT, and T1 relaxation time(T1Rt), extracellular volume fraction(ECVf), intravoxel incoherent motion-based perfusion fraction(PF), and magnetization transfer ratio(MTR) on mpMRI of pancreas were compared. 20 renal donors(for DECT) and 20 patients with renal mass(for mpMRI) served as controls. Results NIC of pancreas in controls and progressive grades of CP were 0.24 ± 0.05, 0.80 ± 0.18, 1.06 ± 0.23, 1.40 ± 0.36, FF were 9.28  ±  5.89, 14.19  ±  5.29, 17.31  ±  5.99, 29.32  ±  12.22, T1Rt were 590.11 ± 61.13, 801.93 ± 211.01, 1006.79 ± 352.18, 1388.01 ± 312.23ms, ECVf were 0.07 ± 0.03, 0.30 ± 0.12, 0.41 ± 0.12, 0.53 ± 0.13, PF were 0.38 ± 0.04, 0.28 ± 0.07, 0.25 ± 0.09, 0.21 ± 0.05 and MTR were 0.12 ± 0.03, 0.15 ± 0.06, 0.21 ± 0.07, 0.26 ± 0.06, respectively. There were significant differences for all quantitative parameters between controls and mild CP; for NIC, PF, and ECVf between controls and progressive CP grades ( p