Real‐life hypoglycaemia partially blunts the inflammatory response to experimental hypoglycaemia in people with type 1 diabetes

Aim To determine whether recent repeated exposure to real‐life hypoglycaemia affects the pro‐inflammatory response during a hypoglycemia episode. Materials and Methods This was a post hoc analysis of a hyperinsulinaemic normoglycaemic‐hypoglycaemic clamp study, involving 40 participants with type 1...

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Published in:Diabetes, obesity & metabolism obesity & metabolism, 2024-09, Vol.26 (9), p.3696-3704
Main Authors: Ajie, Mandala, Heck, Julia I. P., Verhulst, Clementine E. M., Fabricius, Therese W., Hendriksz, Marijn S., McCrimmon, Rory J., Pedersen‐Bjergaard, Ulrik, Galan, Bastiaan, Stienstra, Rinke, Tack, Cees J.
Format: Article
Language:English
Subjects:
Adult
Blood Glucose - analysis
Blood Glucose - metabolism
continuous glucose monitoring
Diabetes
Diabetes mellitus (insulin dependent)
Diabetes Mellitus, Type 1 - blood
Diabetes Mellitus, Type 1 - complications
Diabetes Mellitus, Type 1 - immunology
Female
FLT3L protein
Glucose Clamp Technique
Granulocytes - metabolism
Humans
Hypoglycemia
Hypoglycemia - blood
Inflammation
Inflammation - blood
Insulin - blood
Leukocytes (granulocytic)
Lymphocytes
Male
Middle Aged
real‐life hypoglycaemia
TWEAK protein
type 1 diabetes
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Summary:Aim To determine whether recent repeated exposure to real‐life hypoglycaemia affects the pro‐inflammatory response during a hypoglycemia episode. Materials and Methods This was a post hoc analysis of a hyperinsulinaemic normoglycaemic‐hypoglycaemic clamp study, involving 40 participants with type 1 diabetes. Glucose levels 1 week before the clamp were monitored using a Freestyle Libre 1. Blood was drawn during normoglycaemia and hypoglycaemia, and 24 hours after resolution of hypoglycaemia for measurements of inflammatory responses and counterregulatory hormone levels. We determined the relationship between the frequency and duration of spontaneous hypoglycaemia, and time below range (TBR) and the inflammatory response to experimental hypoglycaemia. Results On average, participants experienced 0.79 (0.43, 1.14) hypoglycaemia episodes per day, with a duration of 78 (47, 110) minutes and TBR of 5.5% (2.8%, 8.5%). TBR and hypoglycaemia frequency were inversely associated with the increase in circulating granulocyte and lymphocyte counts during experimental hypoglycaemia (P 
ISSN:1462-8902
1463-1326
1463-1326
DOI:10.1111/dom.15712