Cascade 1,3-Diploar Cycloaddition and Lactamization for Diastereoselective Synthesis of Pyrrolidinedione-Fused Tetrahydropyrroloisoindolones

A cascade reaction sequence of 1,3-dipolar cycloaddition and lactamization for the synthesis of tetrahydropyrroloisoindolone derivatives is developed. This efficient one-pot synthesis generates four bonds and two heterocyclic rings in a diastereoselective manner. Only 2 equiv of H O are produced as...

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Bibliographic Details
Published in:Journal of organic chemistry 2024-06, Vol.89 (12), p.9125
Main Authors: Jiang, Chao, Yan, Shenghu, Zhang, Yue, Zhang, Qiang, Ma, Xiaoming, Zhang, Wei
Format: Article
Language:English
Online Access:Get full text
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Summary:A cascade reaction sequence of 1,3-dipolar cycloaddition and lactamization for the synthesis of tetrahydropyrroloisoindolone derivatives is developed. This efficient one-pot synthesis generates four bonds and two heterocyclic rings in a diastereoselective manner. Only 2 equiv of H O are produced as the side product.
ISSN:1520-6904
1520-6904
DOI:10.1021/acs.joc.4c00875