Amelioration activity of the high bioaccessible chrysanthemum (Gongju) phenolics on alcohol-induced oxidative injury in AML-12 cells

The main bioavailable phenolics from of Gongju (GJ) and their mechanism for hepato-protection remain unclear. To select the GJ phenolics with high bioavailability, chrysanthemum digestion and Caco-2 cells were used and their hepato-protective potential were examined by using AML-12 cells. The digest...

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Published in:Food chemistry 2024-11, Vol.457, p.140092, Article 140092
Main Authors: Ma, Yi-Long, Li, Zhi, Wu, Zheng-Fang, Wu, Qian-Lan, Guo, Xin, Shang, Ya-Fang, Thakur, Kiran, Wei, Zhao-Jun
Format: Article
Language:English
Subjects:
3,5-dicaffeoylquinic
AML-12
Antioxidants - chemistry
Antioxidants - pharmacology
Caco-2
Caco-2 Cells
Catalase - metabolism
Cell Line
Chrysanthemum - chemistry
GJ extract
Humans
In vitro digestion
Malondialdehyde - metabolism
Oxidation injury
Oxidative Stress - drug effects
Phenolics
Phenols - chemistry
Phenols - pharmacology
Plant Extracts - chemistry
Plant Extracts - pharmacology
Superoxide Dismutase - metabolism
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Summary:The main bioavailable phenolics from of Gongju (GJ) and their mechanism for hepato-protection remain unclear. To select the GJ phenolics with high bioavailability, chrysanthemum digestion and Caco-2 cells were used and their hepato-protective potential were examined by using AML-12 cells. The digestive recovery and small intestinal transit rate of the main phenolic compounds ranged from 28.52 to 69.53% and 6.57% ∼ 15.50%, respectively. Among them, chlorogenic acid, 3,5-dicaffeoylquinic acid, and 1,5-dicaffeoylquinic acid, showed higher small intestinal transit rates and digestive recoveries. Furthermore, we found that by increasing intracellular Catalase (CAT) and Superoxide dismutase (SOD) viability and lowering Malondialdehyde (MDA) level (P 
ISSN:0308-8146
1873-7072
1873-7072
DOI:10.1016/j.foodchem.2024.140092