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Amelioration activity of the high bioaccessible chrysanthemum (Gongju) phenolics on alcohol-induced oxidative injury in AML-12 cells
The main bioavailable phenolics from of Gongju (GJ) and their mechanism for hepato-protection remain unclear. To select the GJ phenolics with high bioavailability, chrysanthemum digestion and Caco-2 cells were used and their hepato-protective potential were examined by using AML-12 cells. The digest...
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| Published in: | Food chemistry 2024-11, Vol.457, p.140092, Article 140092 |
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| creator | Ma, Yi-Long Li, Zhi Wu, Zheng-Fang Wu, Qian-Lan Guo, Xin Shang, Ya-Fang Thakur, Kiran Wei, Zhao-Jun |
| description | The main bioavailable phenolics from of Gongju (GJ) and their mechanism for hepato-protection remain unclear. To select the GJ phenolics with high bioavailability, chrysanthemum digestion and Caco-2 cells were used and their hepato-protective potential were examined by using AML-12 cells. The digestive recovery and small intestinal transit rate of the main phenolic compounds ranged from 28.52 to 69.53% and 6.57% ∼ 15.50%, respectively. Among them, chlorogenic acid, 3,5-dicaffeoylquinic acid, and 1,5-dicaffeoylquinic acid, showed higher small intestinal transit rates and digestive recoveries. Furthermore, we found that by increasing intracellular Catalase (CAT) and Superoxide dismutase (SOD) viability and lowering Malondialdehyde (MDA) level (P |
| doi_str_mv | 10.1016/j.foodchem.2024.140092 |
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•In vitro digestion and absorption profiles of Gongju were characterized in AML-12 cells.•Three phenolic compounds with high bioavailability in GJ were screened out.•3,5-Dicaffeoylquinic acid was the phenolic substance with the highest bioavailability and antioxidant capacity.•Pretreatment with 3,5-dicaffeoylquinic acid significantly enhanced the anti-oxidant enzyme activities in AML-12 cells.</description><identifier>ISSN: 0308-8146</identifier><identifier>ISSN: 1873-7072</identifier><identifier>EISSN: 1873-7072</identifier><identifier>DOI: 10.1016/j.foodchem.2024.140092</identifier><identifier>PMID: 38901347</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>3,5-dicaffeoylquinic ; AML-12 ; Antioxidants - chemistry ; Antioxidants - pharmacology ; Caco-2 ; Caco-2 Cells ; Catalase - metabolism ; Cell Line ; Chrysanthemum - chemistry ; GJ extract ; Humans ; In vitro digestion ; Malondialdehyde - metabolism ; Oxidation injury ; Oxidative Stress - drug effects ; Phenolics ; Phenols - chemistry ; Phenols - pharmacology ; Plant Extracts - chemistry ; Plant Extracts - pharmacology ; Superoxide Dismutase - metabolism</subject><ispartof>Food chemistry, 2024-11, Vol.457, p.140092, Article 140092</ispartof><rights>2023</rights><rights>Copyright © 2023. Published by Elsevier Ltd.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c315t-cbb63aba65f483f571f9d4f8f4e9f3b2344b0f591c24ad6b05984ad5998cd8a23</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38901347$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ma, Yi-Long</creatorcontrib><creatorcontrib>Li, Zhi</creatorcontrib><creatorcontrib>Wu, Zheng-Fang</creatorcontrib><creatorcontrib>Wu, Qian-Lan</creatorcontrib><creatorcontrib>Guo, Xin</creatorcontrib><creatorcontrib>Shang, Ya-Fang</creatorcontrib><creatorcontrib>Thakur, Kiran</creatorcontrib><creatorcontrib>Wei, Zhao-Jun</creatorcontrib><title>Amelioration activity of the high bioaccessible chrysanthemum (Gongju) phenolics on alcohol-induced oxidative injury in AML-12 cells</title><title>Food chemistry</title><addtitle>Food Chem</addtitle><description>The main bioavailable phenolics from of Gongju (GJ) and their mechanism for hepato-protection remain unclear. To select the GJ phenolics with high bioavailability, chrysanthemum digestion and Caco-2 cells were used and their hepato-protective potential were examined by using AML-12 cells. The digestive recovery and small intestinal transit rate of the main phenolic compounds ranged from 28.52 to 69.53% and 6.57% ∼ 15.50%, respectively. Among them, chlorogenic acid, 3,5-dicaffeoylquinic acid, and 1,5-dicaffeoylquinic acid, showed higher small intestinal transit rates and digestive recoveries. Furthermore, we found that by increasing intracellular Catalase (CAT) and Superoxide dismutase (SOD) viability and lowering Malondialdehyde (MDA) level (P < 0.05), 3,5-dicaffeoylquinic acid significantly mitigated the oxidative damage of AML-12 liver cells more than the other two phenolics. Our results demonstrated that 3,5-dicaffeoylquninic acid was the primary phenolic compounds in GJ that effectively reduced liver damage, providing a theoretical basis for the development of GJ as a potentially useful resource for hepatoprotective diet.
[Display omitted]
•In vitro digestion and absorption profiles of Gongju were characterized in AML-12 cells.•Three phenolic compounds with high bioavailability in GJ were screened out.•3,5-Dicaffeoylquinic acid was the phenolic substance with the highest bioavailability and antioxidant capacity.•Pretreatment with 3,5-dicaffeoylquinic acid significantly enhanced the anti-oxidant enzyme activities in AML-12 cells.</description><subject>3,5-dicaffeoylquinic</subject><subject>AML-12</subject><subject>Antioxidants - chemistry</subject><subject>Antioxidants - pharmacology</subject><subject>Caco-2</subject><subject>Caco-2 Cells</subject><subject>Catalase - metabolism</subject><subject>Cell Line</subject><subject>Chrysanthemum - chemistry</subject><subject>GJ extract</subject><subject>Humans</subject><subject>In vitro digestion</subject><subject>Malondialdehyde - metabolism</subject><subject>Oxidation injury</subject><subject>Oxidative Stress - drug effects</subject><subject>Phenolics</subject><subject>Phenols - chemistry</subject><subject>Phenols - pharmacology</subject><subject>Plant Extracts - chemistry</subject><subject>Plant Extracts - pharmacology</subject><subject>Superoxide Dismutase - metabolism</subject><issn>0308-8146</issn><issn>1873-7072</issn><issn>1873-7072</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><recordid>eNqFUU1v1DAQtRCIbgt_ofKxHLKMYydxbqwqKJUWcYGz5Y9x4yiJFztZsXd-OFlty5XTjDTvzZt5j5BbBlsGrP7Yb32MznY4bksoxZYJgLZ8RTZMNrxooClfkw1wkIVkor4i1zn3AFACk2_JFZctMC6aDfmzG3EIMek5xIlqO4djmE80ejp3SLvw1FETorYWcw5mQGq7dMp6WqfjMtK7hzg99csHeuhwikOwmZ7XDDZ2cSjC5BaLjsbfwa0CR6Rh6pd0WgvdfdsXrKQWhyG_I2-8HjK-f6435OeXzz_uvxb77w-P97t9YTmr5sIaU3NtdF15IbmvGuZbJ7z0AlvPTcmFMOCrltlSaFcbqFq5NlXbSuukLvkNubvsPaT4a8E8qzHk8wV6wrhkxaEByZuKwQqtL1CbYs4JvTqkMOp0UgzUOQHVq5cE1DkBdUlgJd4-ayxmRPeP9mL5Cvh0AeD66TFgUtkGnFafQkI7KxfD_zT-AmFenJw</recordid><startdate>20241101</startdate><enddate>20241101</enddate><creator>Ma, Yi-Long</creator><creator>Li, Zhi</creator><creator>Wu, Zheng-Fang</creator><creator>Wu, Qian-Lan</creator><creator>Guo, Xin</creator><creator>Shang, Ya-Fang</creator><creator>Thakur, Kiran</creator><creator>Wei, Zhao-Jun</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20241101</creationdate><title>Amelioration activity of the high bioaccessible chrysanthemum (Gongju) phenolics on alcohol-induced oxidative injury in AML-12 cells</title><author>Ma, Yi-Long ; Li, Zhi ; Wu, Zheng-Fang ; Wu, Qian-Lan ; Guo, Xin ; Shang, Ya-Fang ; Thakur, Kiran ; Wei, Zhao-Jun</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c315t-cbb63aba65f483f571f9d4f8f4e9f3b2344b0f591c24ad6b05984ad5998cd8a23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>3,5-dicaffeoylquinic</topic><topic>AML-12</topic><topic>Antioxidants - chemistry</topic><topic>Antioxidants - pharmacology</topic><topic>Caco-2</topic><topic>Caco-2 Cells</topic><topic>Catalase - metabolism</topic><topic>Cell Line</topic><topic>Chrysanthemum - chemistry</topic><topic>GJ extract</topic><topic>Humans</topic><topic>In vitro digestion</topic><topic>Malondialdehyde - metabolism</topic><topic>Oxidation injury</topic><topic>Oxidative Stress - drug effects</topic><topic>Phenolics</topic><topic>Phenols - chemistry</topic><topic>Phenols - pharmacology</topic><topic>Plant Extracts - chemistry</topic><topic>Plant Extracts - pharmacology</topic><topic>Superoxide Dismutase - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ma, Yi-Long</creatorcontrib><creatorcontrib>Li, Zhi</creatorcontrib><creatorcontrib>Wu, Zheng-Fang</creatorcontrib><creatorcontrib>Wu, Qian-Lan</creatorcontrib><creatorcontrib>Guo, Xin</creatorcontrib><creatorcontrib>Shang, Ya-Fang</creatorcontrib><creatorcontrib>Thakur, Kiran</creatorcontrib><creatorcontrib>Wei, Zhao-Jun</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Food chemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ma, Yi-Long</au><au>Li, Zhi</au><au>Wu, Zheng-Fang</au><au>Wu, Qian-Lan</au><au>Guo, Xin</au><au>Shang, Ya-Fang</au><au>Thakur, Kiran</au><au>Wei, Zhao-Jun</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Amelioration activity of the high bioaccessible chrysanthemum (Gongju) phenolics on alcohol-induced oxidative injury in AML-12 cells</atitle><jtitle>Food chemistry</jtitle><addtitle>Food Chem</addtitle><date>2024-11-01</date><risdate>2024</risdate><volume>457</volume><spage>140092</spage><pages>140092-</pages><artnum>140092</artnum><issn>0308-8146</issn><issn>1873-7072</issn><eissn>1873-7072</eissn><abstract>The main bioavailable phenolics from of Gongju (GJ) and their mechanism for hepato-protection remain unclear. To select the GJ phenolics with high bioavailability, chrysanthemum digestion and Caco-2 cells were used and their hepato-protective potential were examined by using AML-12 cells. The digestive recovery and small intestinal transit rate of the main phenolic compounds ranged from 28.52 to 69.53% and 6.57% ∼ 15.50%, respectively. Among them, chlorogenic acid, 3,5-dicaffeoylquinic acid, and 1,5-dicaffeoylquinic acid, showed higher small intestinal transit rates and digestive recoveries. Furthermore, we found that by increasing intracellular Catalase (CAT) and Superoxide dismutase (SOD) viability and lowering Malondialdehyde (MDA) level (P < 0.05), 3,5-dicaffeoylquinic acid significantly mitigated the oxidative damage of AML-12 liver cells more than the other two phenolics. Our results demonstrated that 3,5-dicaffeoylquninic acid was the primary phenolic compounds in GJ that effectively reduced liver damage, providing a theoretical basis for the development of GJ as a potentially useful resource for hepatoprotective diet.
[Display omitted]
•In vitro digestion and absorption profiles of Gongju were characterized in AML-12 cells.•Three phenolic compounds with high bioavailability in GJ were screened out.•3,5-Dicaffeoylquinic acid was the phenolic substance with the highest bioavailability and antioxidant capacity.•Pretreatment with 3,5-dicaffeoylquinic acid significantly enhanced the anti-oxidant enzyme activities in AML-12 cells.</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>38901347</pmid><doi>10.1016/j.foodchem.2024.140092</doi></addata></record> |
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| subjects | 3,5-dicaffeoylquinic AML-12 Antioxidants - chemistry Antioxidants - pharmacology Caco-2 Caco-2 Cells Catalase - metabolism Cell Line Chrysanthemum - chemistry GJ extract Humans In vitro digestion Malondialdehyde - metabolism Oxidation injury Oxidative Stress - drug effects Phenolics Phenols - chemistry Phenols - pharmacology Plant Extracts - chemistry Plant Extracts - pharmacology Superoxide Dismutase - metabolism |
| title | Amelioration activity of the high bioaccessible chrysanthemum (Gongju) phenolics on alcohol-induced oxidative injury in AML-12 cells |
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