Industrializing methanotrophs and other methylotrophic bacteria: from bioengineering to product recovery

Microbes that use the single-carbon substrates methanol and methane offer great promise to bioindustry along with substantial environmental benefits. Methanotrophs and other methylotrophs can be engineered and optimized to produce a wide range of products, from biopolymers to biofuels and beyond. Wh...

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Bibliographic Details
Published in:Current opinion in biotechnology 2024-08, Vol.88, p.103167, Article 103167
Main Authors: Sauvageau, Dominic, Stein, Lisa Y, Arenas, Elizabeth, Das, Shibashis, Iacobelli, Maryssa, Lawley, Mark, Lazic, Marina, Rondón, Fabián L, Weiblen, Cerrise
Format: Article
Language:English
Subjects:
Bacteria - genetics
Bacteria - metabolism
Bioengineering - methods
Biofuels - microbiology
Bioreactors - microbiology
Industrial Microbiology - methods
Methane - metabolism
Methanol - metabolism
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Summary:Microbes that use the single-carbon substrates methanol and methane offer great promise to bioindustry along with substantial environmental benefits. Methanotrophs and other methylotrophs can be engineered and optimized to produce a wide range of products, from biopolymers to biofuels and beyond. While significant limitations remain, including delivery of single-carbon feedstock to bioreactors, efficient growth, and scale-up, these challenges are being addressed and notable improvements have been rapid. Development of expression chassis, use of genome-scale and regulatory models based on omics data, improvements in bioreactor design and operation, and development of green product recovery schemes are enabling the rapid development of single-carbon bioconversion in the industrial space.
ISSN:0958-1669
1879-0429
1879-0429
DOI:10.1016/j.copbio.2024.103167