Plasma metabolomics changes comparing daytime to overnight infusions of home parenteral nutrition in adult patients with short bowel syndrome: Secondary analysis of a clinical trial

Home parenteral nutrition (HPN) is often cycled nocturnally and is expected to result in glucose intolerance and sleep disruption partly due to circadian misalignment. This study aimed to define the metabolic response when HPN is cycled during the daytime compared to overnight. This secondary analys...

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Bibliographic Details
Published in:Clinical nutrition ESPEN 2024-08, Vol.62, p.28-32
Main Authors: Dashti, Hassan S., Sevilla-Gonzalez, Magdalena, Mogensen, Kris M., Winkler, Marion F., Compher, Charlene
Format: Article
Language:English
Subjects:
Adult
Chronobiology
Circadian Rhythm - physiology
Circadian rhythms
Female
Home parenteral nutrition
Humans
Male
Metabolomics
Middle Aged
Nutrition
Parenteral Nutrition, Home
Short Bowel Syndrome - blood
Short Bowel Syndrome - therapy
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Summary:Home parenteral nutrition (HPN) is often cycled nocturnally and is expected to result in glucose intolerance and sleep disruption partly due to circadian misalignment. This study aimed to define the metabolic response when HPN is cycled during the daytime compared to overnight. This secondary analysis leveraged samples from a clinical trial in adults with short bowel syndrome consuming HPN (ClinicalTrials.gov: NCT04743960). Enrolled patients received 1 week of HPN overnight followed by 1 week of HPN during the daytime. Fasting blood samples were collected following each study period and global metabolic profiles were examined from plasma samples. Differential metabolite abundance was determined from normalized and scaled data using adjusted Linear Models for MicroArray Data models followed by pathway enrichment analysis. Nine patients (mean age, 52.6 years; 78% female; mean BMI 20.7 kg/m2) provided samples. Among 622 identified metabolites, changes were observed in 36 metabolites at Punadj < 0.05 with higher abundance of fatty acids, long-chain and polyunsaturated fatty acids (Dihomo-gamma-linolenic acid, arachidonate (20:4n6), docosahexaenoate (DHA; 22:6n3)) and glycerolipids with daytime infusions. Enrichment analysis identified changes in pathways related to the biosynthesis of unsaturated fatty acids, d-arginine, and d-ornithine metabolism, and linoleic acid metabolism (Punadj
ISSN:2405-4577
2405-4577
DOI:10.1016/j.clnesp.2024.04.025