Loading…
Plasma metabolomics changes comparing daytime to overnight infusions of home parenteral nutrition in adult patients with short bowel syndrome: Secondary analysis of a clinical trial
Home parenteral nutrition (HPN) is often cycled nocturnally and is expected to result in glucose intolerance and sleep disruption partly due to circadian misalignment. This study aimed to define the metabolic response when HPN is cycled during the daytime compared to overnight. This secondary analys...
Saved in:
| Published in: | Clinical nutrition ESPEN 2024-08, Vol.62, p.28-32 |
|---|---|
| Main Authors: | , , , , |
| Format: | Article |
| Language: | English |
| Subjects: | |
| Citations: | Items that this one cites Items that cite this one |
| Online Access: | Get full text |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| cited_by | cdi_FETCH-LOGICAL-c408t-4f3a8fd8e7ebca8a527f818d0583328b26e1340fd75f354918a124c20b23deeb3 |
|---|---|
| cites | cdi_FETCH-LOGICAL-c408t-4f3a8fd8e7ebca8a527f818d0583328b26e1340fd75f354918a124c20b23deeb3 |
| container_end_page | 32 |
| container_issue | |
| container_start_page | 28 |
| container_title | Clinical nutrition ESPEN |
| container_volume | 62 |
| creator | Dashti, Hassan S. Sevilla-Gonzalez, Magdalena Mogensen, Kris M. Winkler, Marion F. Compher, Charlene |
| description | Home parenteral nutrition (HPN) is often cycled nocturnally and is expected to result in glucose intolerance and sleep disruption partly due to circadian misalignment. This study aimed to define the metabolic response when HPN is cycled during the daytime compared to overnight.
This secondary analysis leveraged samples from a clinical trial in adults with short bowel syndrome consuming HPN (ClinicalTrials.gov: NCT04743960). Enrolled patients received 1 week of HPN overnight followed by 1 week of HPN during the daytime. Fasting blood samples were collected following each study period and global metabolic profiles were examined from plasma samples. Differential metabolite abundance was determined from normalized and scaled data using adjusted Linear Models for MicroArray Data models followed by pathway enrichment analysis.
Nine patients (mean age, 52.6 years; 78% female; mean BMI 20.7 kg/m2) provided samples. Among 622 identified metabolites, changes were observed in 36 metabolites at Punadj < 0.05 with higher abundance of fatty acids, long-chain and polyunsaturated fatty acids (Dihomo-gamma-linolenic acid, arachidonate (20:4n6), docosahexaenoate (DHA; 22:6n3)) and glycerolipids with daytime infusions. Enrichment analysis identified changes in pathways related to the biosynthesis of unsaturated fatty acids, d-arginine, and d-ornithine metabolism, and linoleic acid metabolism (Punadj |
| doi_str_mv | 10.1016/j.clnesp.2024.04.025 |
| format | article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_3070839388</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S2405457724001207</els_id><sourcerecordid>3070839388</sourcerecordid><originalsourceid>FETCH-LOGICAL-c408t-4f3a8fd8e7ebca8a527f818d0583328b26e1340fd75f354918a124c20b23deeb3</originalsourceid><addsrcrecordid>eNp9kd9qFDEUxgdRbKl9A5FcerNr_s1OxgtBilqhUMH2OmSSMztZMsmaZFr2wXy_nnareCUcOIHvd77Dydc0bxldM8o2H3ZrGyKU_ZpTLtcUi7cvmlMuabuSbde9_Od90pyXsqMU5_peMvq6ORGqp6yXm9Pm949gymzIDNUMKaTZ20LsZOIWsKd5b7KPW-LMofoZSE0k3UGOfjtV4uO4FJ9iIWkkU0IZaYgVsgkkLjX7iipixLglVFSrR7mQe18nUqaUKxnSPQRSDtFlNPhIfoJN0Zl8ICaacCj-ydwQG3z0Fn3R1YQ3zavRhALnz_2suf365ebicnV1_e37xeerlZVU1ZUchVGjU9DBYI0yLe9GxZSjrRKCq4FvgAlJR9e1o2hlz5RhXFpOBy4cwCDOmvdH331OvxYoVc--WAjBREhL0YJ2VIleKIWoPKI2p1IyjHqf_YyHaEb1Y2Z6p4-Z6cfMNMXiLY69e96wDDO4v0N_EkLg0xEAvPPOQ9bF4i9acD6Drdol__8ND-W7rxo</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>3070839388</pqid></control><display><type>article</type><title>Plasma metabolomics changes comparing daytime to overnight infusions of home parenteral nutrition in adult patients with short bowel syndrome: Secondary analysis of a clinical trial</title><source>ScienceDirect Freedom Collection</source><creator>Dashti, Hassan S. ; Sevilla-Gonzalez, Magdalena ; Mogensen, Kris M. ; Winkler, Marion F. ; Compher, Charlene</creator><creatorcontrib>Dashti, Hassan S. ; Sevilla-Gonzalez, Magdalena ; Mogensen, Kris M. ; Winkler, Marion F. ; Compher, Charlene</creatorcontrib><description>Home parenteral nutrition (HPN) is often cycled nocturnally and is expected to result in glucose intolerance and sleep disruption partly due to circadian misalignment. This study aimed to define the metabolic response when HPN is cycled during the daytime compared to overnight.
This secondary analysis leveraged samples from a clinical trial in adults with short bowel syndrome consuming HPN (ClinicalTrials.gov: NCT04743960). Enrolled patients received 1 week of HPN overnight followed by 1 week of HPN during the daytime. Fasting blood samples were collected following each study period and global metabolic profiles were examined from plasma samples. Differential metabolite abundance was determined from normalized and scaled data using adjusted Linear Models for MicroArray Data models followed by pathway enrichment analysis.
Nine patients (mean age, 52.6 years; 78% female; mean BMI 20.7 kg/m2) provided samples. Among 622 identified metabolites, changes were observed in 36 metabolites at Punadj < 0.05 with higher abundance of fatty acids, long-chain and polyunsaturated fatty acids (Dihomo-gamma-linolenic acid, arachidonate (20:4n6), docosahexaenoate (DHA; 22:6n3)) and glycerolipids with daytime infusions. Enrichment analysis identified changes in pathways related to the biosynthesis of unsaturated fatty acids, d-arginine, and d-ornithine metabolism, and linoleic acid metabolism (Punadj<0.05).
Daytime infusions of HPN may result in changes in circulating lipids and amino acid composing metabolic pathways previously implicated in circadian rhythms. As this is the first untargeted metabolomics study of HPN, larger studies are needed.</description><identifier>ISSN: 2405-4577</identifier><identifier>EISSN: 2405-4577</identifier><identifier>DOI: 10.1016/j.clnesp.2024.04.025</identifier><identifier>PMID: 38901946</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>Adult ; Chronobiology ; Circadian Rhythm - physiology ; Circadian rhythms ; Female ; Home parenteral nutrition ; Humans ; Male ; Metabolomics ; Middle Aged ; Nutrition ; Parenteral Nutrition, Home ; Short Bowel Syndrome - blood ; Short Bowel Syndrome - therapy</subject><ispartof>Clinical nutrition ESPEN, 2024-08, Vol.62, p.28-32</ispartof><rights>2024 European Society for Clinical Nutrition and Metabolism</rights><rights>Copyright © 2024 European Society for Clinical Nutrition and Metabolism. Published by Elsevier Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c408t-4f3a8fd8e7ebca8a527f818d0583328b26e1340fd75f354918a124c20b23deeb3</citedby><cites>FETCH-LOGICAL-c408t-4f3a8fd8e7ebca8a527f818d0583328b26e1340fd75f354918a124c20b23deeb3</cites><orcidid>0000-0001-9510-3018 ; 0000-0002-1650-679X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38901946$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Dashti, Hassan S.</creatorcontrib><creatorcontrib>Sevilla-Gonzalez, Magdalena</creatorcontrib><creatorcontrib>Mogensen, Kris M.</creatorcontrib><creatorcontrib>Winkler, Marion F.</creatorcontrib><creatorcontrib>Compher, Charlene</creatorcontrib><title>Plasma metabolomics changes comparing daytime to overnight infusions of home parenteral nutrition in adult patients with short bowel syndrome: Secondary analysis of a clinical trial</title><title>Clinical nutrition ESPEN</title><addtitle>Clin Nutr ESPEN</addtitle><description>Home parenteral nutrition (HPN) is often cycled nocturnally and is expected to result in glucose intolerance and sleep disruption partly due to circadian misalignment. This study aimed to define the metabolic response when HPN is cycled during the daytime compared to overnight.
This secondary analysis leveraged samples from a clinical trial in adults with short bowel syndrome consuming HPN (ClinicalTrials.gov: NCT04743960). Enrolled patients received 1 week of HPN overnight followed by 1 week of HPN during the daytime. Fasting blood samples were collected following each study period and global metabolic profiles were examined from plasma samples. Differential metabolite abundance was determined from normalized and scaled data using adjusted Linear Models for MicroArray Data models followed by pathway enrichment analysis.
Nine patients (mean age, 52.6 years; 78% female; mean BMI 20.7 kg/m2) provided samples. Among 622 identified metabolites, changes were observed in 36 metabolites at Punadj < 0.05 with higher abundance of fatty acids, long-chain and polyunsaturated fatty acids (Dihomo-gamma-linolenic acid, arachidonate (20:4n6), docosahexaenoate (DHA; 22:6n3)) and glycerolipids with daytime infusions. Enrichment analysis identified changes in pathways related to the biosynthesis of unsaturated fatty acids, d-arginine, and d-ornithine metabolism, and linoleic acid metabolism (Punadj<0.05).
Daytime infusions of HPN may result in changes in circulating lipids and amino acid composing metabolic pathways previously implicated in circadian rhythms. As this is the first untargeted metabolomics study of HPN, larger studies are needed.</description><subject>Adult</subject><subject>Chronobiology</subject><subject>Circadian Rhythm - physiology</subject><subject>Circadian rhythms</subject><subject>Female</subject><subject>Home parenteral nutrition</subject><subject>Humans</subject><subject>Male</subject><subject>Metabolomics</subject><subject>Middle Aged</subject><subject>Nutrition</subject><subject>Parenteral Nutrition, Home</subject><subject>Short Bowel Syndrome - blood</subject><subject>Short Bowel Syndrome - therapy</subject><issn>2405-4577</issn><issn>2405-4577</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><recordid>eNp9kd9qFDEUxgdRbKl9A5FcerNr_s1OxgtBilqhUMH2OmSSMztZMsmaZFr2wXy_nnareCUcOIHvd77Dydc0bxldM8o2H3ZrGyKU_ZpTLtcUi7cvmlMuabuSbde9_Od90pyXsqMU5_peMvq6ORGqp6yXm9Pm949gymzIDNUMKaTZ20LsZOIWsKd5b7KPW-LMofoZSE0k3UGOfjtV4uO4FJ9iIWkkU0IZaYgVsgkkLjX7iipixLglVFSrR7mQe18nUqaUKxnSPQRSDtFlNPhIfoJN0Zl8ICaacCj-ydwQG3z0Fn3R1YQ3zavRhALnz_2suf365ebicnV1_e37xeerlZVU1ZUchVGjU9DBYI0yLe9GxZSjrRKCq4FvgAlJR9e1o2hlz5RhXFpOBy4cwCDOmvdH331OvxYoVc--WAjBREhL0YJ2VIleKIWoPKI2p1IyjHqf_YyHaEb1Y2Z6p4-Z6cfMNMXiLY69e96wDDO4v0N_EkLg0xEAvPPOQ9bF4i9acD6Drdol__8ND-W7rxo</recordid><startdate>202408</startdate><enddate>202408</enddate><creator>Dashti, Hassan S.</creator><creator>Sevilla-Gonzalez, Magdalena</creator><creator>Mogensen, Kris M.</creator><creator>Winkler, Marion F.</creator><creator>Compher, Charlene</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-9510-3018</orcidid><orcidid>https://orcid.org/0000-0002-1650-679X</orcidid></search><sort><creationdate>202408</creationdate><title>Plasma metabolomics changes comparing daytime to overnight infusions of home parenteral nutrition in adult patients with short bowel syndrome: Secondary analysis of a clinical trial</title><author>Dashti, Hassan S. ; Sevilla-Gonzalez, Magdalena ; Mogensen, Kris M. ; Winkler, Marion F. ; Compher, Charlene</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c408t-4f3a8fd8e7ebca8a527f818d0583328b26e1340fd75f354918a124c20b23deeb3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Adult</topic><topic>Chronobiology</topic><topic>Circadian Rhythm - physiology</topic><topic>Circadian rhythms</topic><topic>Female</topic><topic>Home parenteral nutrition</topic><topic>Humans</topic><topic>Male</topic><topic>Metabolomics</topic><topic>Middle Aged</topic><topic>Nutrition</topic><topic>Parenteral Nutrition, Home</topic><topic>Short Bowel Syndrome - blood</topic><topic>Short Bowel Syndrome - therapy</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Dashti, Hassan S.</creatorcontrib><creatorcontrib>Sevilla-Gonzalez, Magdalena</creatorcontrib><creatorcontrib>Mogensen, Kris M.</creatorcontrib><creatorcontrib>Winkler, Marion F.</creatorcontrib><creatorcontrib>Compher, Charlene</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Clinical nutrition ESPEN</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Dashti, Hassan S.</au><au>Sevilla-Gonzalez, Magdalena</au><au>Mogensen, Kris M.</au><au>Winkler, Marion F.</au><au>Compher, Charlene</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Plasma metabolomics changes comparing daytime to overnight infusions of home parenteral nutrition in adult patients with short bowel syndrome: Secondary analysis of a clinical trial</atitle><jtitle>Clinical nutrition ESPEN</jtitle><addtitle>Clin Nutr ESPEN</addtitle><date>2024-08</date><risdate>2024</risdate><volume>62</volume><spage>28</spage><epage>32</epage><pages>28-32</pages><issn>2405-4577</issn><eissn>2405-4577</eissn><abstract>Home parenteral nutrition (HPN) is often cycled nocturnally and is expected to result in glucose intolerance and sleep disruption partly due to circadian misalignment. This study aimed to define the metabolic response when HPN is cycled during the daytime compared to overnight.
This secondary analysis leveraged samples from a clinical trial in adults with short bowel syndrome consuming HPN (ClinicalTrials.gov: NCT04743960). Enrolled patients received 1 week of HPN overnight followed by 1 week of HPN during the daytime. Fasting blood samples were collected following each study period and global metabolic profiles were examined from plasma samples. Differential metabolite abundance was determined from normalized and scaled data using adjusted Linear Models for MicroArray Data models followed by pathway enrichment analysis.
Nine patients (mean age, 52.6 years; 78% female; mean BMI 20.7 kg/m2) provided samples. Among 622 identified metabolites, changes were observed in 36 metabolites at Punadj < 0.05 with higher abundance of fatty acids, long-chain and polyunsaturated fatty acids (Dihomo-gamma-linolenic acid, arachidonate (20:4n6), docosahexaenoate (DHA; 22:6n3)) and glycerolipids with daytime infusions. Enrichment analysis identified changes in pathways related to the biosynthesis of unsaturated fatty acids, d-arginine, and d-ornithine metabolism, and linoleic acid metabolism (Punadj<0.05).
Daytime infusions of HPN may result in changes in circulating lipids and amino acid composing metabolic pathways previously implicated in circadian rhythms. As this is the first untargeted metabolomics study of HPN, larger studies are needed.</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>38901946</pmid><doi>10.1016/j.clnesp.2024.04.025</doi><tpages>5</tpages><orcidid>https://orcid.org/0000-0001-9510-3018</orcidid><orcidid>https://orcid.org/0000-0002-1650-679X</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 2405-4577 |
| ispartof | Clinical nutrition ESPEN, 2024-08, Vol.62, p.28-32 |
| issn | 2405-4577 2405-4577 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_3070839388 |
| source | ScienceDirect Freedom Collection |
| subjects | Adult Chronobiology Circadian Rhythm - physiology Circadian rhythms Female Home parenteral nutrition Humans Male Metabolomics Middle Aged Nutrition Parenteral Nutrition, Home Short Bowel Syndrome - blood Short Bowel Syndrome - therapy |
| title | Plasma metabolomics changes comparing daytime to overnight infusions of home parenteral nutrition in adult patients with short bowel syndrome: Secondary analysis of a clinical trial |
| url | http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-07T16%3A41%3A59IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Plasma%20metabolomics%20changes%20comparing%20daytime%20to%20overnight%20infusions%20of%20home%20parenteral%20nutrition%20in%20adult%20patients%20with%20short%20bowel%20syndrome:%20Secondary%20analysis%20of%20a%20clinical%20trial&rft.jtitle=Clinical%20nutrition%20ESPEN&rft.au=Dashti,%20Hassan%20S.&rft.date=2024-08&rft.volume=62&rft.spage=28&rft.epage=32&rft.pages=28-32&rft.issn=2405-4577&rft.eissn=2405-4577&rft_id=info:doi/10.1016/j.clnesp.2024.04.025&rft_dat=%3Cproquest_cross%3E3070839388%3C/proquest_cross%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c408t-4f3a8fd8e7ebca8a527f818d0583328b26e1340fd75f354918a124c20b23deeb3%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=3070839388&rft_id=info:pmid/38901946&rfr_iscdi=true |