The diagnostic value of salivary C-reactive protein in neonatal infections: a meta-analysis

Purpose C-reactive protein (CRP), as an acute phase protein, is a sensitive indicator of neonatal bacterial infection. Some recent studies have shown that there is a correlation between CRP levels in serum and saliva, and using saliva to detect CRP levels is expected to be an ideal and non-invasive...

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Bibliographic Details
Published in:Infection 2024-10, Vol.52 (5), p.2071-2082
Main Authors: Wang, Xinning, Fei, Qiang, Yuan, Tianming
Format: Article
Language:English
Subjects:
Acute phase proteins
Bacterial diseases
Bacterial infections
Biomarkers
Biomarkers - analysis
Biomarkers - blood
C-reactive protein
C-Reactive Protein - analysis
Diagnostic systems
Family Medicine
General Practice
Humans
Infant, Newborn
Infant, Newborn, Diseases - diagnosis
Infant, Newborn, Diseases - microbiology
Infections
Infectious Diseases
Internal Medicine
Medicine
Medicine & Public Health
Meta-analysis
Neonates
Observational studies
Proteins
Review
Saliva
Saliva - chemistry
Sensitivity and Specificity
Citations: Items that this one cites
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Summary:Purpose C-reactive protein (CRP), as an acute phase protein, is a sensitive indicator of neonatal bacterial infection. Some recent studies have shown that there is a correlation between CRP levels in serum and saliva, and using saliva to detect CRP levels is expected to be an ideal and non-invasive method to predict neonatal infection. The purpose of this Meta-analysis was to evaluate the diagnostic value of salivary CRP for neonatal infection. Methods We searched PubMed, Embase, Web of Science, and Scopus databases in October 2023 and included observational studies that examined salivary CRP in newborns with bacterial infections. Data was extracted regarding the methodology, participant characteristics, and outcome measures. Results Nine articles were included, with a total of 696 newborns. Salivary CRP levels are significantly higher in neonates with infections compared to non-infected group (SMD = 0.58, 95%CI [0.40–0.76], P  
ISSN:0300-8126
1439-0973
1439-0973
DOI:10.1007/s15010-024-02328-4