The ability of microRNAs to regulate the immune response in ischemia/reperfusion inflammatory pathways

MicroRNAs play a crucial role in regulating the immune responses induced by ischemia/reperfusion injury. Through their ability to modulate gene expression, microRNAs adjust immune responses by targeting specific genes and signaling pathways. This review focuses on the impact of microRNAs on the infl...

Full description

Saved in:
Bibliographic Details
Published in:Genes and immunity 2024-08, Vol.25 (4), p.277-296
Main Authors: Artimovič, Peter, Špaková, Ivana, Macejková, Ema, Pribulová, Timea, Rabajdová, Miroslava, Mareková, Mária, Zavacká, Martina
Format: Article
Language:English
Subjects:
631/208/200
631/250/256/2177
631/250/256/2515
631/250/256/2516
631/250/516/1909
Angiogenesis
Animals
Biomedical and Life Sciences
Biomedicine
Cancer Research
Cell death
Cytokines
Gene Expression
Gene Expression Regulation
Homeostasis
Human Genetics
Humans
Hypoxia
Immune response
Immunity (Disease)
Immunology
Immunoregulation
Inflammation
Inflammation - genetics
Inflammation - immunology
Inflammation - metabolism
Ischemia
Kinases
MicroRNAs
MicroRNAs - genetics
MicroRNAs - metabolism
miRNA
Mitochondrial DNA
Neutrophils
Reperfusion
Reperfusion Injury - genetics
Reperfusion Injury - immunology
Reperfusion Injury - metabolism
Review Article
Signal Transduction
Therapeutic applications
Trauma
Tumor necrosis factor-TNF
Citations: Items that this one cites
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:MicroRNAs play a crucial role in regulating the immune responses induced by ischemia/reperfusion injury. Through their ability to modulate gene expression, microRNAs adjust immune responses by targeting specific genes and signaling pathways. This review focuses on the impact of microRNAs on the inflammatory pathways triggered during ischemia/reperfusion injury and highlights their ability to modulate inflammation, playing a critical role in the pathophysiology of ischemia/reperfusion injury. Dysregulated expression of microRNAs contributes to the pathogenesis of ischemia/reperfusion injury, therefore targeting specific microRNAs offers an opportunity to restore immune homeostasis and improve patient outcomes. Understanding the complex network of immunoregulatory microRNAs could provide novel therapeutic interventions aimed at attenuating excessive inflammation and preserving tissue integrity.
ISSN:1476-5470
1466-4879
1476-5470
DOI:10.1038/s41435-024-00283-6