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The ability of microRNAs to regulate the immune response in ischemia/reperfusion inflammatory pathways
MicroRNAs play a crucial role in regulating the immune responses induced by ischemia/reperfusion injury. Through their ability to modulate gene expression, microRNAs adjust immune responses by targeting specific genes and signaling pathways. This review focuses on the impact of microRNAs on the infl...
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| Published in: | Genes and immunity 2024-08, Vol.25 (4), p.277-296 |
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| Main Authors: | , , , , , , |
| Format: | Article |
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| container_end_page | 296 |
| container_issue | 4 |
| container_start_page | 277 |
| container_title | Genes and immunity |
| container_volume | 25 |
| creator | Artimovič, Peter Špaková, Ivana Macejková, Ema Pribulová, Timea Rabajdová, Miroslava Mareková, Mária Zavacká, Martina |
| description | MicroRNAs play a crucial role in regulating the immune responses induced by ischemia/reperfusion injury. Through their ability to modulate gene expression, microRNAs adjust immune responses by targeting specific genes and signaling pathways. This review focuses on the impact of microRNAs on the inflammatory pathways triggered during ischemia/reperfusion injury and highlights their ability to modulate inflammation, playing a critical role in the pathophysiology of ischemia/reperfusion injury. Dysregulated expression of microRNAs contributes to the pathogenesis of ischemia/reperfusion injury, therefore targeting specific microRNAs offers an opportunity to restore immune homeostasis and improve patient outcomes. Understanding the complex network of immunoregulatory microRNAs could provide novel therapeutic interventions aimed at attenuating excessive inflammation and preserving tissue integrity. |
| doi_str_mv | 10.1038/s41435-024-00283-6 |
| format | article |
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| subjects | 631/208/200 631/250/256/2177 631/250/256/2515 631/250/256/2516 631/250/516/1909 Angiogenesis Animals Biomedical and Life Sciences Biomedicine Cancer Research Cell death Cytokines Gene Expression Gene Expression Regulation Homeostasis Human Genetics Humans Hypoxia Immune response Immunity (Disease) Immunology Immunoregulation Inflammation Inflammation - genetics Inflammation - immunology Inflammation - metabolism Ischemia Kinases MicroRNAs MicroRNAs - genetics MicroRNAs - metabolism miRNA Mitochondrial DNA Neutrophils Reperfusion Reperfusion Injury - genetics Reperfusion Injury - immunology Reperfusion Injury - metabolism Review Article Signal Transduction Therapeutic applications Trauma Tumor necrosis factor-TNF |
| title | The ability of microRNAs to regulate the immune response in ischemia/reperfusion inflammatory pathways |
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