Integrating platelet reactivity in the age, creatinine and ejection fraction score to predict clinical outcomes following percutaneous coronary intervention in patients with chronic coronary syndrome: the PR-ACEF score

To evaluate if integrating platelet reactivity (PR) evaluation in the original age, creatinine and ejection fraction (ACEF) score could improve the diagnostic accuracy of the model in patients with stable coronary artery disease (CAD). We enrolled patients treated with percutaneous coronary interven...

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Bibliographic Details
Published in:Heart and vessels 2024-12, Vol.39 (12), p.1009-1017
Main Authors: Paolucci, Luca, Mangiacapra, Fabio, Viscusi, Michele Mattia, Sergio, Sara, Bressi, Edoardo, Colaiori, Iginio, Ricottini, Elisabetta, Cavallari, Ilaria, Nusca, Annunziata, Melfi, Rosetta, Ussia, Gian Paolo, Grigioni, Francesco
Format: Article
Language:English
Subjects:
Age Factors
Aged
Angioplasty
Biomarkers - blood
Biomedical Engineering and Bioengineering
Blood Platelets
Cardiac Surgery
Cardiology
Cardiovascular disease
Coronary artery disease
Coronary Artery Disease - blood
Coronary Artery Disease - diagnosis
Coronary Artery Disease - mortality
Coronary Artery Disease - physiopathology
Coronary Artery Disease - surgery
Creatinine
Creatinine - blood
Death
Diagnostic systems
Ejection fraction
Female
Heart diseases
Humans
Male
Medicine
Medicine & Public Health
Middle Aged
Mortality
Myocardial infarction
Myocardial Infarction - diagnosis
Original Article
Percutaneous Coronary Intervention - adverse effects
Platelet Activation - physiology
Platelets
Predictive Value of Tests
Prognosis
Resampling
Retrospective Studies
Risk Assessment - methods
Risk Factors
Stroke Volume - physiology
Time Factors
Treatment Outcome
Vascular Surgery
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Summary:To evaluate if integrating platelet reactivity (PR) evaluation in the original age, creatinine and ejection fraction (ACEF) score could improve the diagnostic accuracy of the model in patients with stable coronary artery disease (CAD). We enrolled patients treated with percutaneous coronary intervention between 2010 and 2011. High PR was included in the model (PR-ACEF). Co-primary end points were a composite of death/myocardial infarction (MI) and major adverse cardiovascular events (MACE). Overall, 471 patients were enrolled. Compared to the ACEF score, the PR-ACEF showed an improved diagnostic accuracy for death/MI (AUC 0.610 vs 0.670, p  
ISSN:0910-8327
1615-2573
1615-2573
DOI:10.1007/s00380-024-02430-5