Astaxanthin treatment decreases pro‐inflammatory cytokines and improves reproductive outcomes in patients with polycystic ovary syndrome undergoing assisted reproductive technology: A randomized clinical trial

Research question In a randomized, triple-blind, placebo-controlled clinical trial (RCT), we investigated the effect of astaxanthin (AST) on pro-inflammatory cytokines, oxidative stress (OS) markers, and assisted reproductive technology (ART) outcomes in 44 infertile Polycystic Ovary Syndrome (PCOS)...

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Published in:Inflammopharmacology 2024-08, Vol.32 (4), p.2337-2347
Main Authors: Fereidouni, Farzane, Kashani, Ladan, Amidi, Fardin, Khodarahmian, Mahshad, Zhaeentan, Shahrzad, ardehjani, Negar Ajabi, Rastegar, Tayebeh
Format: Article
Language:English
Subjects:
Adult
Allergology
Biomedical and Life Sciences
Biomedicine
Cytokines - metabolism
Dermatology
Female
Follicular Fluid - metabolism
Gastroenterology
Humans
Immunology
Infertility, Female - drug therapy
Interleukin-1beta - blood
Interleukin-1beta - metabolism
Original Article
Oxidative Stress - drug effects
Pharmacology/Toxicology
Polycystic Ovary Syndrome - drug therapy
Pregnancy
Reproductive Techniques, Assisted
Rheumatology
Treatment Outcome
Xanthophylls - administration & dosage
Xanthophylls - pharmacology
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Summary:Research question In a randomized, triple-blind, placebo-controlled clinical trial (RCT), we investigated the effect of astaxanthin (AST) on pro-inflammatory cytokines, oxidative stress (OS) markers, and assisted reproductive technology (ART) outcomes in 44 infertile Polycystic Ovary Syndrome (PCOS) patients. Design Patients with PCOS were randomly divided into two groups. The intervention group received 6 mg AST, and the control group received placebo daily for 8 weeks. Blood samples were obtained from all patients before and after intervention and follicular fluid (FF) was collected during the ART procedure. Interleukin (IL) ‐6, IL‐1β were evaluated from serum samples and FF and OS markers (malondialdehyde [MDA], catalase [CAT], superoxide dismutase [SOD], and reactive oxygen species [ROS]) were measured from FF. The groups were compared for ART outcomes as well. Results A significant decrease in IL-6 and IL-1β concentrations (both, P = 
ISSN:0925-4692
1568-5608
1568-5608
DOI:10.1007/s10787-024-01504-0