Risk of fractures following bariatric surgery with Roux-en-Y gastric bypass or sleeve gastrectomy: a Danish population-based cohort study

• Published in: European journal of endocrinology 2024-07, Vol.191 (1), p.1-8
• Main Authors: Winckelmann, Lotte A, Gribsholt, Sigrid B, Bødkergaard, Katrine, Rejnmark, Lars, Madsen, Lene R, Richelsen, Bjørn
• Format: Article
• Language: English
• Subjects: Adult; Aged; Bariatric Surgery - adverse effects; Cohort Studies; Denmark - epidemiology; Female; Fractures, Bone - epidemiology; Fractures, Bone - etiology; Gastrectomy - adverse effects; Gastric Bypass - adverse effects; Humans; Incidence; Male; Middle Aged; Obesity, Morbid - epidemiology; Obesity, Morbid - surgery; Osteoporotic Fractures - epidemiology; Osteoporotic Fractures - etiology; Postoperative Complications - epidemiology; Postoperative Complications - etiology; Risk Factors
• ISSN: 0804-4643; 1479-683X; 1479-683X
• DOI: 10.1093/ejendo/lvae068

We examined the association between Roux-en-Y gastric bypass (RYGB) or sleeve gastrectomy (SG) and fracture risk, including major osteoporotic fractures (MOF), and the use of anti-osteoporosis medication (AOM). While RYGB is associated with impaired bone health and increased fracture risk, it remains uncertain whether SG has a similar impact and whether this risk is primarily due to MOF or any fracture. We conducted a nationwide cohort study covering patients treated with RYGB (n = 16 121, 10.2-year follow-up) or SG (n = 1509, 3.7-year follow-up), from 2006 to 2018, comparing them with an age- and sex-matched cohort (n = 407 580). We computed incidence rates and adjusted hazard ratios (HRs) with 95% CIs, using Cox regression for any fracture, MOF, and use of AOM with adjustment for comorbidities. Compared with the general population cohort, RYGB was associated with an increased risk of any fracture (HR 1.56 [95% CI, 1.48-1.64]) and MOF (HR 1.49 [1.35-1.64]). Sleeve gastrectomy was associated with an increased risk of any fracture (HR 1.38 [1.13-1.68]), while the HR of MOF was 1.43 (0.97-2.12). The use of AOM was low but similar in all cohorts (approximately 1%). Bariatric surgery increased the risk of any fracture and MOF to similar extend. Risks were similar for RYGB and SG. However, SG had a shorter follow-up than RYGB, and the cohort size was rather small. More research is needed for long-term SG fracture risk assessment. The use of AOM was low in all cohorts.