Constructing an Intent‐to‐Treat Score Index to Predict Survival Outcomes in Pediatric Liver Transplant Recipients

ABSTRACT Background Waitlist and posttransplant outcomes have been widely reported for pediatric liver transplantation. Yet, analyzing these metrics individually fails to provide a holistic perspective for patients and their families. Intent‐to‐treat (ITT) analysis fills this gap by studying the ass...

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Bibliographic Details
Published in:Pediatric transplantation 2024-08, Vol.28 (5), p.e14816-n/a
Main Authors: Montgomery, Ashley, Lang, Anna, Kunisetty, Bhavana, Kamepalli, Spoorthi, Lynn, Jake, Alvarez, Alexandra, Goss, John, Galvan, Nhu Thao Nguyen, Rana, Abbas
Format: Article
Language:English
Subjects:
Adolescent
Ascites
Bilirubin
Child
Child, Preschool
Creatinine
Diabetes mellitus
End Stage Liver Disease - mortality
End Stage Liver Disease - surgery
Female
Humans
Infant
Infant, Newborn
Intention to Treat Analysis
intent‐to‐treat
Liver diseases
Liver Transplantation
Liver transplants
Logistic Models
Male
outcomes
pediatric liver transplantation
Pediatrics
Prognosis
Retrospective Studies
Risk Factors
Statistical analysis
Survival
Waiting Lists - mortality
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Summary:ABSTRACT Background Waitlist and posttransplant outcomes have been widely reported for pediatric liver transplantation. Yet, analyzing these metrics individually fails to provide a holistic perspective for patients and their families. Intent‐to‐treat (ITT) analysis fills this gap by studying the associations between waitlist outcomes, organ availability, and posttransplant outcomes. Our study aimed to construct a predictive index utilizing ITT analysis for pediatric liver transplant recipients (Pedi‐ITT). Methods We performed a retrospective analysis utilizing de‐identified data provided by the United Network for Organ Sharing (UNOS) from March 1, 2002, to December 31, 2021. We analyzed data for 12 926 pediatric recipients (age
ISSN:1397-3142
1399-3046
1399-3046
DOI:10.1111/petr.14816