Effects of a medium cut‐off dialyzer on inflammation and cardiac and vascular function in hemodialysis patients with heart failure

• Published in: Hemodialysis international 2024-07, Vol.28 (3), p.326-335
• Main Authors: Ozarli, Irem, Yeter, Hacı Hasan, Sener, Yusuf Ziya, Cebrailov, Cebrail, Yildirim, Tolga, Yilmaz, Rahmi
• Format: Article
• Language: English
• Subjects: diastolic function; expanded; hemodialysis; inflammation; medium cut‐off; pulse wave velocity
• ISSN: 1492-7535; 1542-4758; 1542-4758
• DOI: 10.1111/hdi.13166

Introduction Expanded hemodialysis (HDx) could provide clearance of larger middle‐molecule uremic toxins. We compared the effect of hemodialysis with medium cut‐off membranes and high‐flux (HFHD) membranes regarding changes in inflammation and vascular and left ventricular function. Methods This was a single‐center, prospective, parallel‐group comparative study. Patients were divided into two groups (HDx: 25 patients and HFHD: 26 patients). All measurements were performed at baseline and 12 weeks. Serum c‐reactive protein, interkelukin‐18, pentraxin‐3, β‐2 microglobulin, and brain natriuretic peptide were measured. We used pulse wave velocity and augmentation index to assess arterial stiffness and echocardiography to evaluate left and right ventricular function. Findings We enrolled 51 patients. Although serum c‐reactive protein, interkelukin‐18, pentraxin 3, and β‐2 microglobulin were significantly decreased in the HDx group (p = 0.02, p