A tale of recurrent secretory carcinoma of submandibular gland in an adolescent male: A rare presentation of a rare tumor

Mammary analogue secretory carcinoma (MASC) is a rare salivary gland tumor which shares its histologic, immunohistochemical, and genetic features with the secretory carcinoma (SC) of breast. In this case report, we describe a case of MASC in a young adolescent male with swelling in the right angle o...

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Bibliographic Details
Published in:Diagnostic cytopathology 2024-11, Vol.52 (11), p.E256-E259
Main Authors: Kapatia, Gargi, Kaur, Manjit, Jain, Dhwani, Rajasekaran, Sangamitra, Rajan, Nikhil, Soni, Ankita, Sekar, Aravind
Format: Article
Language:English
Subjects:
Adolescent
Biopsy, Fine-Needle
Cancer
Diagnosis, Differential
Humans
Male
mammary analogue secretory carcinoma
Mammary Analogue Secretory Carcinoma - diagnosis
Mammary Analogue Secretory Carcinoma - genetics
Mammary Analogue Secretory Carcinoma - pathology
MASC
Neoplasm Recurrence, Local - pathology
Salivary Gland Neoplasms - diagnosis
Salivary Gland Neoplasms - pathology
salivary gland tumor
Submandibular Gland - pathology
Submandibular Gland Neoplasms - diagnosis
Submandibular Gland Neoplasms - pathology
Tumors
Citations: Items that this one cites
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Summary:Mammary analogue secretory carcinoma (MASC) is a rare salivary gland tumor which shares its histologic, immunohistochemical, and genetic features with the secretory carcinoma (SC) of breast. In this case report, we describe a case of MASC in a young adolescent male with swelling in the right angle of mandible which is a relatively rare site to present along with its correlation of cytological, histological, and immunohistochemical features. A 16‐year‐old male came with the complaint of swelling in the right angle of mandible since 2 years. Contrast‐enhanced computed tomography (CECT) neck revealed differential diagnosis of nerve sheath tumor, pleomorphic adenoma, and adenoid cystic neoplasm was kept, and subsequently fine‐needle aspiration cytology (FNAC) was done. FNAC was done in which differential diagnosis of myoepithelial neoplasm, acinic cell carcinoma, and SC was given. Surgical excision was done followed by histopathological examination. Immunohistochemistry panel was also applied, and final diagnosis of SC was rendered. SC has distinct cytological, histological, and immunohistochemical features which should be recognized by the pathologists for the appropriate management of the patient.
ISSN:8755-1039
1097-0339
1097-0339
DOI:10.1002/dc.25377