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Relationship between atherosclerotic burden and depressive symptoms in hypertensive patients: A cross-sectional study based on the NHANES database

The relationship between atherosclerotic burden, depressive symptoms, and clinically relevant depression (CRD) in hypertensive patients is unclear. In this study, we used the atherosclerotic index of plasma (AIP) to quantify atherosclerotic burden and explore its association with depressive symptoms...

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Bibliographic Details
Published in:Journal of affective disorders 2024-09, Vol.361, p.612-619
Main Authors: Chen, Ting, Qian, Yuan, Deng, Xingli
Format: Article
Language:English
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Summary:The relationship between atherosclerotic burden, depressive symptoms, and clinically relevant depression (CRD) in hypertensive patients is unclear. In this study, we used the atherosclerotic index of plasma (AIP) to quantify atherosclerotic burden and explore its association with depressive symptoms and CRD in hypertensive patients. Hypertension-diagnosed patients were extracted from the National Health and Nutrition Examination Survey (NHANES) database. The relationships between AIP and depressive symptoms and CRD risk in patients were examined through the weighted logistic regression and the weighted linear regression models. Restrictive cubic spline curves were employed to analyze potential nonlinear associations between AIP and outcome indicators. Additionally, subgroup analyses and intergroup interaction tests were conducted. The AIP was considerably associated with the severity of depressive symptoms in hypertensive patients, according to the findings of weighted linear regression. Weighted logistic regression analysis showed that high AIP was significantly associated with a high risk of clinically relevant depression in hypertensive patients. This trend was consistent across various subgroups within the population. AIP was observed to be a significant risk factor for clinically relevant depression in hypertensive patients. Atherosclerotic burden in hypertensive patients was significantly associated with the severity of their depressive symptoms. •The atherosclerotic index of plasma (AIP) is a recently discovered indicator of atherosclerotic burden that is easy and quick to obtain.•AIP was significantly and positively correlated with depressive symptom severity (PHQ-9 score).•AIP significantly increased the risk of clinically relevant depression (PHQ-9 score >= 10).•The study population was those diagnosed with hypertension in the NHANES database. We analyzed using complex sampling-based analyses. The results are nationally representative.
ISSN:0165-0327
1573-2517
1573-2517
DOI:10.1016/j.jad.2024.06.087