Pancreatic juice cytology for diagnosing invasive pancreatic carcinoma/high-grade pancreatic intraepithelial neoplasia without visible tumors on endoscopic ultrasound

Pancreatic ductal adenocarcinoma (PDAC) with a diameter ≤10 mm and high-grade pancreatic intraepithelial neoplasia (HG-PanIN) require pre-operative diagnosis. Most cases present only indirect imaging findings without visible tumors on endoscopic ultrasound (EUS). Therefore, EUS-guided fine-needle as...

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Bibliographic Details
Published in:Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.] 2024-08, Vol.24 (5), p.740-746
Main Authors: Sagami, Ryota, Mizukami, Kazuhiro, Nishikiori, Hidefumi, Sato, Takao, Fujiwara, Shozo, Kawamoto, Yusuke, Ome, Yusuke, Honda, Goro, Horiguchi, Shin-ichiro, Sato, Keiji, Murakami, Kazunari
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Carcinoma in Situ - diagnostic imaging
Carcinoma in Situ - pathology
Carcinoma, Pancreatic Ductal - diagnostic imaging
Carcinoma, Pancreatic Ductal - pathology
Cytodiagnosis
Endoscopic ultrasound-guided fine-needle aspiration
Endosonography - methods
Female
Humans
Male
Middle Aged
Pancreatic cancer
Pancreatic ductal carcinoma
Pancreatic Juice - cytology
Pancreatic neoplasms
Pancreatic Neoplasms - diagnosis
Pancreatic Neoplasms - diagnostic imaging
Pancreatic Neoplasms - pathology
Retrospective Studies
Sensitivity and Specificity
Citations: Items that this one cites
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Summary:Pancreatic ductal adenocarcinoma (PDAC) with a diameter ≤10 mm and high-grade pancreatic intraepithelial neoplasia (HG-PanIN) require pre-operative diagnosis. Most cases present only indirect imaging findings without visible tumors on endoscopic ultrasound (EUS). Therefore, EUS-guided fine-needle aspiration/biopsy is not applicable. An alternative diagnostic method is pancreatic juice cytology (PJC) via endoscopic naso-pancreatic drainage (ENPD-PJC), which is not the standard practice. This study aimed to investigate ENPD-PJC for diagnosing suspected PDAC/HG-PanIN cases without visible tumors on EUS. Data of patients with suspected PDAC/HG-PanIN without visible tumors who underwent PJC were retrospectively evaluated. One PJC sample was collected during endoscopic retrograde pancreatography (ERP-PJC), and 12 samples were collected during ENPD-PJC, 3-hourly for cytological analysis. ERP-PJC, ERP/ENPD-PJC, and ENPD-PJC positivity indicated cytologically positive samples. Patients with positive/negative PJC with follow-up for
ISSN:1424-3903
1424-3911
1424-3911
DOI:10.1016/j.pan.2024.06.006