Efficient Trifluoromethylation of Halogenated Hydrocarbons Using Novel (bpy)Cu(O2CCF2SO2F)2 Reagent

• Published in: Molecules (Basel, Switzerland) Switzerland), 2024-06, Vol.29 (12)
• Main Authors: Wu, Xiong, Qiu, Xin, Lou, Wenrun, Zhang, Shengxue, Zhang, Chaoyi, Ma, Xiaoyu, Liu, Chao
• Format: Article
• Language: English
• ISSN: 1420-3049; 1420-3049
• DOI: 10.3390/molecules29122849

This study introduces a novel trifluoromethylating reagent, [(bpy)Cu(O2CCF2SO2F)2], notable for not only its practical synthesis from cost-effective starting materials and scalability but also its nonhygroscopic nature. The reagent demonstrates high efficiency in facilitating trifluoromethylation reactions with various halogenated hydrocarbons, yielding products in good yields and exhibiting broad functional group compatibility. The development of [(bpy)Cu(O2CCF2SO2F)2] represents an advancement in the field of organic synthesis, potentially serving as a valuable addition to the arsenal of existing trifluoromethylating agents.This study introduces a novel trifluoromethylating reagent, [(bpy)Cu(O2CCF2SO2F)2], notable for not only its practical synthesis from cost-effective starting materials and scalability but also its nonhygroscopic nature. The reagent demonstrates high efficiency in facilitating trifluoromethylation reactions with various halogenated hydrocarbons, yielding products in good yields and exhibiting broad functional group compatibility. The development of [(bpy)Cu(O2CCF2SO2F)2] represents an advancement in the field of organic synthesis, potentially serving as a valuable addition to the arsenal of existing trifluoromethylating agents.