Advances in regulation of homeostasis through chromatin modifications by airway commensals

Commensal bacteria are residents of the human airway where they interact with both colonizing pathogens and host respiratory epithelial cells of this mucosal surface. It is here that commensals exert their influence through host signaling cascades, host transcriptional responses and host immunity, a...

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Bibliographic Details
Published in:Current opinion in microbiology 2024-08, Vol.80, p.102505, Article 102505
Main Authors: Connor, Michael G, Hamon, Melanie A
Format: Article
Language:English
Subjects:
Animals
Bacteria - genetics
Bacteria - metabolism
Chromatin - genetics
Chromatin - metabolism
Chromatin Assembly and Disassembly
Homeostasis
Humans
Microbiota
Respiratory System - immunology
Respiratory System - metabolism
Respiratory System - microbiology
Symbiosis
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Summary:Commensal bacteria are residents of the human airway where they interact with both colonizing pathogens and host respiratory epithelial cells of this mucosal surface. It is here that commensals exert their influence through host signaling cascades, host transcriptional responses and host immunity, all of which are rooted in chromatin remodeling and histone modifications. Recent studies show that airway commensals impact host chromatin, but compared the what is known for gut commensals, the field remains in its infancy. The mechanisms by which airway commensals regulate respiratory health and homeostasis through chromatin modifications is of increasing interest, specifically since their displacement precedes the increased potential for respiratory disease. Herein we will discuss recent advances and intriguing avenues of future work aimed at deciphering how airway commensals protect and influence respiratory health.
ISSN:1369-5274
1879-0364
1879-0364
DOI:10.1016/j.mib.2024.102505