Surface bioactivation of Polyetheretherketone (PEEK) by magnesium chondroitin sulfate (MgCS) as orthopedic implants for reconstruction of skeletal defects

Polyether-ether-ketone (PEEK) is clinically used as a bio-implant for the healing of skeletal defects. However, the osseointegration of clinical-sized bone grafts remains limited. In this study, surface-porous PEEK was created by using a sulfonation method and a metal-polysaccharide complex MgCS was...

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Bibliographic Details
Published in:International journal of biological macromolecules 2024-08, Vol.274 (Pt 2), p.133435, Article 133435
Main Authors: Xu, Lei, Li, Meixin, Ma, Fenbo, Zhang, Hongan, Liang, Xiajun, Cheng, Guoyun, Li, Ying, Ruiz-Ortega, L.I., Sun, Dawei, Tang, Bin, Qin, Chenghe
Format: Article
Language:English
Subjects:
Animals
Benzophenones
Biocompatible Materials - chemistry
Biocompatible Materials - pharmacology
Bone defects
Chondroitin Sulfates - chemistry
Chondroitin Sulfates - pharmacology
Ketones - chemistry
Ketones - pharmacology
Magnesium - pharmacology
Male
Osseointegration - drug effects
Osteogenesis - drug effects
PEEK
Polyethylene Glycols - chemistry
Polymers - chemistry
Porosity
Prostheses and Implants
Rats
Rats, Sprague-Dawley
Surface modification
Surface Properties
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Summary:Polyether-ether-ketone (PEEK) is clinically used as a bio-implant for the healing of skeletal defects. However, the osseointegration of clinical-sized bone grafts remains limited. In this study, surface-porous PEEK was created by using a sulfonation method and a metal-polysaccharide complex MgCS was introduced on the surface of sulfonated PEEK to form MgCS@SPEEK. The as-prepared MgCS@SPEEK was found to have a porous surface with good hydrophilicity and bioactivity. This was followed by an investigation into whether MgCS loaded onto sulfonated PEEK surfaces could promote osseointegration and angiogenesis. The in vitro results showed that MgCS@SPEEK had a positive effect on reducing the expression levels of inflammatory genes and promoting osteogenesis and angiogenesis-related genes expression levels. Furthermore, porous MgCS@SPEEK was implanted in critical-sized rat tibial defects for in vivo evaluation of osseointegration. The micro-computed tomography evaluation results revealed substantial bone formation at 4 and 8 weeks. Collectively, these findings indicate that MgCS@SPEEK could provide improved osseointegration and an attractive strategy for orthopaedic applications.
ISSN:0141-8130
1879-0003
1879-0003
DOI:10.1016/j.ijbiomac.2024.133435