Reaching new lands: Updating the distribution of Angiostrongylus cantonensis in South America with the first record in Argentina

• Published in: Zoonoses and public health 2024-09, Vol.71 (6), p.748-754
• Main Authors: Hancke, Diego, Guzman, Noelia, Tripodi, Mariel, Muschetto, Emiliano, Suárez, Olga Virginia
• Format: Article
• Language: English
• Subjects: Angiostrongylus cantonensis; Angiostrongylus cantonensis - genetics; Angiostrongylus cantonensis - isolation & purification; Animals; Argentina; Argentina - epidemiology; Bioaccumulation; COI protein; Commercial ships; Economic conditions; Environmental health; Environmental impact; Flooded areas; Gene sequencing; Geographical distribution; Haplotypes; Health surveillance; Hosts; Lagoons; Leukocytes (eosinophilic); Life cycle; Meningitis; Nature reserves; Parasites; Phylogeny; Public health; Pulmonary arteries; Pulmonary artery; Rats; Rattus norvegicus; Rodent Diseases - epidemiology; Rodent Diseases - parasitology; Snails; Strongylida Infections - epidemiology; Strongylida Infections - parasitology; Strongylida Infections - veterinary; urban environments
• ISSN: 1863-1959; 1863-2378; 1863-2378
• DOI: 10.1111/zph.13163

Background Angiostrongylus cantonensis, commonly known as the rat lungworm, is a metastrongyloid nematode found primarily not only in tropical and subtropical regions but also in temperate areas and considered the leading cause of eosinophilic meningitis in humans. Synanthropic rodents such as Rattus norvegicus and Rattus rattus are the most frequent definitive hosts of this parasite. Methods and Results The presence of this parasite was detected in the pulmonary arteries of three specimens of R. norvegicus in the city of Buenos Aires representing the species' southernmost known record in natural hosts. Species confirmation was achieved through partial sequences of 18S and COI genes. By comparing the COI gene sequences with those available in GenBank through the construction of a haplotype network, we obtained that the analysed specimen presents high similarity with those reported in Japan and Southeast Asia. Conclusions All infected rats were captured in an area surrounding a port with significant import and export activity, suggesting that A. cantonensis may have been introduced through commercial ships. Specifically, the parasite was detected in a neighbourhood with vulnerable socio‐economic conditions and in a nature reserve, which exhibit biotic and abiotic characteristics conducive to sustaining high‐density rat populations, scattered waste, areas of spontaneous vegetation, debris accumulation and flooded areas or lagoons offering suitable habitats for intermediate hosts such as snails. Thus, the close proximity of the port to these sites creates a favourable ecological context for the establishment of A. cantonensis. This study shows the need to conduct research to detect A. cantonensis in non‐endemic areas but with the characteristics that promote its arrival and development of its life cycle in order to implement control measures to prevent expansion of this parasite and its transmission to humans and other animals.