Role of Optical Coherence Tomography in Vasculitis-Associated Pulmonary Hypertension and Chronic Thromboembolic Pulmonary Hypertension

• Published in: Circulation Journal 2024/09/25, Vol.88(10), pp.1620-1628
• Main Authors: Avci, Burçak Kilickiran, Seyahi, Emire, Polat, Fuat, Kolak, Zeynep, Yalman, Hakan, Atahan, Ersan, Ongen, Hurrem Gul, Ongen, Zeki
• Format: Article
• Language: English
• Subjects: Adult; Aged; Behcet disease; Behcet Syndrome - complications; Behcet Syndrome - diagnostic imaging; Behcet Syndrome - pathology; Chronic Disease; Chronic thromboembolic pulmonary hypertension; Female; Humans; Hypertension, Pulmonary - diagnostic imaging; Hypertension, Pulmonary - etiology; Idiopathic pulmonary arterial hypertension; Male; Middle Aged; Optical coherence tomography; Pulmonary Artery - diagnostic imaging; Pulmonary Artery - pathology; Pulmonary Embolism - complications; Pulmonary Embolism - diagnostic imaging; Takayasu arteritis; Takayasu Arteritis - complications; Takayasu Arteritis - diagnostic imaging; Tomography, Optical Coherence
• ISSN: 1346-9843; 1347-4820; 1347-4820
• DOI: 10.1253/circj.CJ-24-0254

Background: Identifying and understanding the microstructural changes within the wall of the pulmonary artery (PA) is crucial for elucidating disease mechanisms and guiding treatment strategies. We assessed the utility of optical coherence tomography (OCT) in identifying such changes within segmental/subsegmental PAs and compared the morphological variations in WHO group 4 pulmonary hypertension associated with Behcet Disease (BD), Takayasu arteritis (TA) and chronic thromboembolic pulmonary hypertension (CTEPH). Idiopathic pulmonary arterial hypertension (IPAH) patients served as controls.Methods and Results: A total of 197 cross-sectional images were analyzed from 20 consecutive patients. BD patients exhibited lower %wall area and mean wall thickness (MWT) compared with CTEPH, TA and, IPAH patients. TA patients showed a notably higher %wall area, which was significant in IPAH and BD patients. Variations in %wall area measurements were observed across distinct cross-sectional segments of the PA within individual patients (22% in CTEPH, 19% in BD, 16% in TA, 23% in IPAH patients). Intravascular webs, bands, and thrombi were observed in BD and CTEPH patients. OCT provided clear delineation of vascular wall calcifications and adventitial vasa vasorum. No procedure-related complications were observed.Conclusions: PA involvement differs among the various etiologies of PH, with the PA being heterogeneously affected. OCT offers promise in elucidating microstructural vascular wall changes and providing insights into disease mechanisms and treatment effects.